J C Froehlich
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Explore the profile of J C Froehlich including associated specialties, affiliations and a list of published articles.
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34
Citations
545
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Recent Articles
1.
Froehlich J
Subst Use Misuse
. 2010 Jul;
45(11):1727-41.
PMID: 20590397
The use of selective breeding to produce animal models for the study of alcohol abuse and alcoholism represents one of the major advances in the field of alcohol research. Rats...
2.
Chester J, Price C, Froehlich J
Alcohol Clin Exp Res
. 2002 Feb;
26(1):19-27.
PMID: 11821650
Background: The purpose of the present study was to determine whether alcohol-naïve rats selectively bred for alcohol preference or nonpreference differ in alcohol withdrawal severity using two sets of rat...
3.
Chester J, Grahame N, Li T, Lumeng L, Froehlich J
Behav Pharmacol
. 2001 Dec;
12(6-7):535-43.
PMID: 11742148
Sensitization to the locomotor-stimulant effects of drugs is thought to play an important role in the development of drug-seeking behaviour. We hypothesized that the ability of acamprosate to reduce alcohol...
4.
Froehlich J, Stewart R, Li T, Mosemiller A, McCullough D, Ho M, et al.
Alcohol Clin Exp Res
. 2001 Apr;
25(3):370-6.
PMID: 11290847
Background: The study of within-session alcohol tolerance in the rat has been hampered by methodological difficulties related to the measurement of dependent variables at predictable blood alcohol concentrations (BAC) during...
5.
Grahame N, Mosemiller A, Low M, Froehlich J
Pharmacol Biochem Behav
. 2001 Feb;
67(4):759-66.
PMID: 11166066
Alcohol-induced activation of the opioid system may contribute to the reinforcing properties of alcohol. This study investigated whether elimination of beta-endorphin (BE) synthesis via site-directed mutagenesis in embryonic stem cells...
6.
Froehlich J, Zink R, Li T, CHRISTIAN J
Alcohol Clin Exp Res
. 2000 Apr;
24(3):265-77.
PMID: 10776662
Background: Hormonal responses to alcohol have been reported to differ in subjects with and without a family history of alcoholism which suggests that alcohol-induced hormonal changes might be used to...
7.
June H, McCane S, Zink R, Portoghese P, Li T, Froehlich J
Psychopharmacology (Berl)
. 1999 Dec;
147(1):81-9.
PMID: 10591872
Rationale: Given that alcoholics drink for different reasons, it is not likely that a single pharmacotherapeutic agent will be equally effective for all alcoholics. Hence, the development of new pharmacotherapeutic...
8.
Badia-Elder N, Mosemiller A, Elder R, Froehlich J
Psychopharmacology (Berl)
. 1999 Aug;
144(3):205-12.
PMID: 10435386
Objective: This study examined whether repeated daily treatment with naloxone prevents expression of a genetic predisposition toward high alcohol drinking in rats selectively bred for alcohol preference (P line). Methods:...
9.
Froehlich J, Badia-Elder N, Zink R, McCullough D, Portoghese P
J Pharmacol Exp Ther
. 1998 Oct;
287(1):284-92.
PMID: 9765348
The effect of blocking delta opioid receptors on alcohol aversion was examined in female alcohol-preferring (P) rats using a conditioned taste aversion (CTA) paradigm. In experiment 1, alcohol naive P...
10.
Li X, Li T, Froehlich J
Brain Res
. 1998 Jun;
794(1):35-47.
PMID: 9630499
Evidence suggests that alcohol-induced activation of the endogenous opioid system is part of a neurobiological mechanism that may be functionally involved in alcohol reinforcement and high alcohol drinking behavior. We...