J C Besnard
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Explore the profile of J C Besnard including associated specialties, affiliations and a list of published articles.
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83
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451
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Recent Articles
11.
Helfenbein J, Sandell J, Halldin C, Chalon S, Emond P, Okubo Y, et al.
Nucl Med Biol
. 1999 Sep;
26(5):491-9.
PMID: 10473187
Several positron emission tomography (PET) radioligands based on the aryl tropane structure have been used for studies on monoamine reuptake sites. RTI-364, RTI-330, and RTI-357 (3-beta-(4'-n-propyl-,4'-iso-propyl-, and 4'-iso-propenyl-phenyl)nortropane-2-beta-carboxylic acid methyl...
12.
Chalon S, Emond P, Bodard S, Vilar M, Thiercelin C, Besnard J, et al.
Synapse
. 1999 Feb;
31(2):134-9.
PMID: 10024010
The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease....
13.
Baulieu J, Ribeiro M, Tranquart F, Chartier J, Guilloteau D, Cottier J, et al.
Nucl Med Commun
. 1999 Feb;
20(1):77-84.
PMID: 9949416
Various parameters are currently used for the semi-quantitative assessment of dopamine D2 receptors and differ according to the delineation of the striatal region of interest (ROI) and the choice of...
14.
Chalon S, Belzung C, Guilloteau D, Leguisquet A, Besnard J, Durand G
J Nutr
. 1998 Dec;
128(12):2512-9.
PMID: 9868201
We studied the effects of a fish oil enriched diet on fatty acid composition of cerebral membranes and on several neurochemical and behavioral variables of monoaminergic function in rats. The...
15.
Emond P, Farde L, Chalon S, Belzung C, Mauclaire V, Chiron J, et al.
Nucl Med Biol
. 1998 Jun;
25(4):405-9.
PMID: 9639303
The cocaine analog beta-CIT is one of the most used compounds for SPET examination of the dopamine transporter in drug abuse and Parkinson's disease. However, the toxicity of this agent...
16.
Guilloteau D, Emond P, Baulieu J, Garreau L, Frangin Y, Pourcelot L, et al.
Nucl Med Biol
. 1998 Jun;
25(4):331-7.
PMID: 9639293
For the diagnosis and follow-up of neurodegenerative diseases, many cocaine derivatives have been proposed as radioligands to explore the dopamine transporter. As none of them have all the criteria of...
17.
Zimmer L, Hembert S, Durand G, Breton P, Guilloteau D, Besnard J, et al.
Neurosci Lett
. 1998 Mar;
240(3):177-81.
PMID: 9502233
The effects of alpha-linolenic acid diet deficiency on rat dopaminergic metabolism were investigated in the frontal cortex of male 2-3 month-old rats using the microdialysis method. Increased basal levels of...
18.
Garreau L, Emond P, Belzung C, Guilloteau D, Frangin Y, Besnard J, et al.
J Pharmacol Exp Ther
. 1997 Jul;
282(1):467-74.
PMID: 9223589
N-(3-Iodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichl orophenyl)nortropane (beta-CDIT), a new iodinated tropane derivative, has been synthesized and radiolabeled with iodine. [125I]beta-CDIT was tested in vitro and ex vivo as a probe for the dopamine transporter...
19.
Emond P, Chalon S, Garreau L, Dognon A, Bodard S, Frangin Y, et al.
Synapse
. 1997 May;
26(1):72-80.
PMID: 9097407
SPECT exploration of the dopamine transporter with tropane derivatives such as beta-CIT has already produced very valuable information in humans. However, the high affinity of this tracer for both dopamine...
20.
Emond P, Garreau L, Chalon S, Boazi M, Caillet M, BRICARD J, et al.
J Med Chem
. 1997 Apr;
40(9):1366-72.
PMID: 9135033
Two novel series of iodinated N-substituted analogs of 2beta-carbomethoxy-3beta-(4'-iodophenyl)tropane (beta-CIT) and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-dis ubstituted phenyl)nortropane were synthesized. They were evaluated for their inhibitory properties on dopamine (DA(T)), serotonin (5-HT(T)), and norepinephrine...