J Barney Bryson
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Explore the profile of J Barney Bryson including associated specialties, affiliations and a list of published articles.
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13
Citations
535
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Recent Articles
1.
Bryson J, Kourgiantaki A, Jiang D, Demosthenous A, Greensmith L
Elife
. 2024 Jan;
12.
PMID: 38236205
Breakdown of neuromuscular junctions (NMJs) is an early pathological hallmark of amyotrophic lateral sclerosis (ALS) that blocks neuromuscular transmission, leading to muscle weakness, paralysis and, ultimately, premature death. Currently, no...
2.
Greensmith L, Bryson J
Amyotroph Lateral Scler Frontotemporal Degener
. 2023 Jul;
:1-7.
PMID: 37489926
Previously, we demonstrated that Amyloid Precursor Protein (APP) contributes to pathology in the SOD1 mouse model of ALS and that genetic ablation of APP in SOD1 mice significantly improved multiple...
3.
Bryson J, Machado C, Lieberam I, Greensmith L
Curr Opin Biotechnol
. 2016 Mar;
40:75-81.
PMID: 27016703
Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as...
4.
Bercsenyi K, Schmieg N, Bryson J, Wallace M, Caccin P, Golding M, et al.
Science
. 2014 Nov;
346(6213):1118-23.
PMID: 25430769
Tetanus neurotoxin (TeNT) is among the most poisonous substances on Earth and a major cause of neonatal death in nonvaccinated areas. TeNT targets the neuromuscular junction (NMJ) with high affinity,...
5.
Bryson J, Machado C, Crossley M, Stevenson D, Bros-Facer V, Burrone J, et al.
Science
. 2014 Apr;
344(6179):94-7.
PMID: 24700859
Damage to the central nervous system caused by traumatic injury or neurological disorders can lead to permanent loss of voluntary motor function and muscle paralysis. Here, we describe an approach...
6.
Bryson J, Hobbs C, Parsons M, Bosch K, Pandraud A, Walsh F, et al.
Hum Mol Genet
. 2012 Jun;
21(17):3871-82.
PMID: 22678056
In amyotrophic lateral sclerosis (ALS), the progressive loss of motor neurons is accompanied by extensive muscle denervation, resulting in paralysis and ultimately death. Upregulation of amyloid beta (A4) precursor protein...
7.
Petros T, Bryson J, Mason C
Dev Neurobiol
. 2010 Jul;
70(11):781-94.
PMID: 20629048
The circuit for binocular vision and stereopsis is established at the optic chiasm, where retinal ganglion cell (RGC) axons diverge into the ipsilateral and contralateral optic tracts. In the mouse...
8.
Ma T, Campana A, Lange P, Lee H, Banerjee K, Bryson J, et al.
J Neurosci
. 2010 Jan;
30(2):739-48.
PMID: 20071539
An ideal therapeutic for stroke or spinal cord injury should promote survival and regeneration in the CNS. Arginase 1 (Arg1) has been shown to protect motor neurons from trophic factor...
9.
Deng K, He H, Qiu J, Lorber B, Bryson J, Filbin M
J Neurosci
. 2009 Jul;
29(30):9545-52.
PMID: 19641117
Adult spinal axons do not spontaneously regenerate after injury. However, if the peripheral branch of dorsal root ganglion neurons is lesioned before lesioning the central branch of the same neurons...
10.
Banks G, Bros-Facer V, Williams H, Chia R, Achilli F, Bryson J, et al.
PLoS One
. 2009 Jul;
4(7):e6218.
PMID: 19593442
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a...