J Ackrell
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Explore the profile of J Ackrell including associated specialties, affiliations and a list of published articles.
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4
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12
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Recent Articles
1.
Muchowski J, Cooper G, Halpern O, Koehler R, Kluge A, Simon R, et al.
J Med Chem
. 1987 May;
30(5):820-3.
PMID: 3572970
5-Aroyl-6-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carbo xylic acids were synthesized and assayed for analgesic and antiinflammatory activity. Several of these compounds, notably the 5-(4-fluoro- and 4-chlorobenzoyl)-6-methyl derivatives 25 and 26 and the 5-(4-methyl-, 4-fluoro-, 4-chloro-,...
2.
Muchowski J, Unger S, Ackrell J, Cheung P, Cooper G, Cook J, et al.
J Med Chem
. 1985 Aug;
28(8):1037-49.
PMID: 4020827
5-Acyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and the homologous pyridine and azepine derivatives were synthesized and assayed for antiinflammatory and analgesic activity. 5-Benzoyl-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylic acid and the corresponding p-methoxy compound 74 were selected for evaluation...
3.
Ackrell J, Antonio Y, Franco F, Landeros R, Leon A, Muchowski J, et al.
J Med Chem
. 1978 Oct;
21(10):1035-44.
PMID: 309946
Acetic acid derivatives of tricyclic systems, such as 6,11-dihydro-11-oxodibenzo[b,e]thiepin, 4,10-dihydro-4-oxo-thieno[2,3-c][1]benzothiepin, dibenzo[b,f]thiepin, dibenz[b,f]oxepin, etc., were synthesized and assayed for antiinflammatory activity. One of the compounds, 6,11-dihydro-11-oxodibenzo[b,e]thiepin-3-acetic acid (52), was chosen for...
4.