J A Vorholt
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Explore the profile of J A Vorholt including associated specialties, affiliations and a list of published articles.
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17
Citations
473
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Recent Articles
1.
Pomper B, Vorholt J
Eur J Biochem
. 2001 Sep;
268(17):4769-75.
PMID: 11532013
Methylobacterium extorquens AM1 possesses a formaldehyde-oxidation pathway that involves enzymes with high sequence identity with enzymes from methanogenic and sulfate-reducing archaea. Here we describe the purification and characterization of formylmethanofuran-tetrahydromethanopterin...
2.
Hagemeier C, Bartoschek S, Griesinger C, Thauer R, Vorholt J
FEBS Lett
. 2001 Apr;
494(1-2):95-8.
PMID: 11297742
MtdA catalyzes the dehydrogenation of N(5),N(10)-methylenetetrahydromethanopterin (methylene-H4MPT) with NADP(+) as electron acceptor. In the reaction two prochiral centers are involved, C14a of methylene-H4MPT and C4 of NADP(+), between which a...
3.
Vorholt J, Marx C, Lidstrom M, Thauer R
J Bacteriol
. 2000 Nov;
182(23):6645-50.
PMID: 11073907
Formaldehyde is toxic for all organisms from bacteria to humans due to its reactivity with biological macromolecules. Organisms that grow aerobically on single-carbon compounds such as methanol and methane face...
4.
Hagemeier C, Chistoserdova L, Lidstrom M, Thauer R, Vorholt J
Eur J Biochem
. 2000 Jun;
267(12):3762-9.
PMID: 10848995
Cell extracts of Methylobacterium extorquens AM1 were recently found to catalyze the dehydrogenation of methylene tetrahydromethanopterin (methylene H4MPT) with NAD+ and NADP+. The purification of a 32-kDa NADP-specific methylene H4MPT...
5.
Bartoschek S, Vorholt J, Thauer R, Geierstanger B, Griesinger C
Eur J Biochem
. 2000 May;
267(11):3130-8.
PMID: 10824097
N-carboxymethanofuran (carbamate) formation from unprotonated methanofuran (MFR) and CO2 is the first reaction in the reduction of CO2 to methane in methanogenic archaea. The reaction proceeds spontaneously. We address here...
6.
Grabarse W, Vaupel M, Vorholt J, Shima S, Thauer R, Wittershagen A, et al.
Structure
. 1999 Nov;
7(10):1257-68.
PMID: 10545331
Background: The reduction of carbon dioxide to methane in methanogenic archaea involves the tetrahydrofolate analogue tetrahydromethanopterin (H(4)MPT) as a C(1) unit carrier. In the third step of this reaction sequence,...
7.
Hans M, Sievers J, Muller U, Bill E, Vorholt J, Linder D, et al.
Eur J Biochem
. 1999 Sep;
265(1):404-14.
PMID: 10491198
Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP,...
8.
Vorholt J, Chistoserdova L, Stolyar S, Thauer R, Lidstrom M
J Bacteriol
. 1999 Sep;
181(18):5750-7.
PMID: 10482517
The methylotrophic proteobacterium Methylobacterium extorquens AM1 possesses tetrahydromethanopterin (H(4)MPT)-dependent enzymes, which are otherwise specific to methanogenic and sulfate-reducing archaea and which have been suggested to be involved in formaldehyde oxidation...
9.
Pomper B, Vorholt J, Chistoserdova L, Lidstrom M, Thauer R
Eur J Biochem
. 1999 Apr;
261(2):475-80.
PMID: 10215859
Recently it was found that Methylobacterium extorquens AM1 contains both tetrahydromethanopterin (H4MPT) and tetrahydrofolate (H4F) as carriers of C1 units. In this paper we report that the aerobic methylotroph contains...
10.
Vorholt J, Chistoserdova L, Lidstrom M, Thauer R
J Bacteriol
. 1998 Oct;
180(20):5351-6.
PMID: 9765566
An NADP-dependent methylene tetrahydromethanopterin (H4MPT) dehydrogenase has recently been proposed to be involved in formaldehyde oxidation to CO2 in Methylobacterium extorquens AM1. We report here on the purification of this...