J A McKeating
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Explore the profile of J A McKeating including associated specialties, affiliations and a list of published articles.
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Articles
73
Citations
3104
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Recent Articles
1.
Fletcher N, Clark A, Balfe P, McKeating J
J Gen Virol
. 2016 Dec;
98(3):405-412.
PMID: 27983476
Preventing virally induced liver disease begins with an understanding of the host factors that define susceptibility to infection. Hepatitis C virus (HCV) is a global health issue, with an estimated...
2.
Meredith L, Hu K, Cheng X, Howard C, Baumert T, Balfe P, et al.
J Gen Virol
. 2015 Oct;
97(1):121-127.
PMID: 26474824
Hepatitis B virus (HBV) is one of the world's major unconquered infections, resulting in progressive liver disease, and current treatments rarely cure infection. A limitation to discovering new therapies is...
3.
Meredith L, Zitzmann N, McKeating J
Antiviral Res
. 2013 Oct;
100(3):636-9.
PMID: 24157306
Inhibitors targeting the hepatitis C virus (HCV) encoded viroporin, p7 prevent virus release in vitro. HCV can transmit by cell-free particle infection of new target cells and via cell-to-cell dependent...
4.
HARRIS H, Clerte C, Farquhar M, Goodall M, Hu K, Rassam P, et al.
Cell Microbiol
. 2012 Nov;
15(3):430-45.
PMID: 23126643
Many viruses target the polarized epithelial apex during host invasion. In contrast, hepatitis C virus (HCV) engages receptors at the basal surface of hepatocytes in the polarized liver parenchyma. Hepatocyte...
5.
Fletcher N, McKeating J
J Viral Hepat
. 2012 Apr;
19(5):301-6.
PMID: 22497808
Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus of the family Flaviviridae that primarily infects hepatocytes, causing acute and chronic liver disease. HCV is also associated with a...
6.
Farquhar M, McKeating J
J Viral Hepat
. 2008 Dec;
15(12):849-54.
PMID: 19087224
Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent...
7.
8.
McKeating J, Zhang L, Logvinoff C, Flint M, Zhang J, Yu J, et al.
J Virol
. 2004 Jul;
78(16):8496-505.
PMID: 15280458
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for virus-cell entry...
9.
Logvinoff C, Major M, Oldach D, Heyward S, Talal A, Balfe P, et al.
Proc Natl Acad Sci U S A
. 2004 Jun;
101(27):10149-54.
PMID: 15220475
Little is known about the role of Abs in determining the outcome of hepatitis C virus (HCV) infection. By using infectious retroviral pseudotypes bearing HCV glycoproteins, we measured neutralizing Ab...
10.
Jeffs S, Shotton C, Balfe P, McKeating J
J Gen Virol
. 2002 Oct;
83(Pt 11):2723-2732.
PMID: 12388808
Removal of the V1-V3 loops from IIIB gp120 results in a protein, PR12, with altered immunogenicity compared to the full-length protein. Polyclonal immune sera raised in rats using PR12 as...