J A McGuiness
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Explore the profile of J A McGuiness including associated specialties, affiliations and a list of published articles.
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9
Citations
52
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Recent Articles
1.
Selley M, McGuiness J, Ardlie N
Thromb Res
. 1996 Sep;
83(6):449-61.
PMID: 8885139
The cholesterol oxidation products (oxysterols) cholest-3,5-diene-7-one, cholestan-5 alpha, 6 alpha-epoxy-3 beta-ol (cholesterol 5 alpha-epoxide), cholestan-5 beta, 6 beta-epoxy-3 beta-ol (cholesterol 5 beta-epoxide), cholest-5-ene-3 beta-ol-7-one (7-ketocholesterol), cholest-5-ene-3 beta, 7 alpha-diol (7...
2.
Selley M, Czeti A, McGuiness J, Ardlie N
Atherosclerosis
. 1994 Nov;
111(1):91-7.
PMID: 7840817
The oxidative modification of low density lipoprotein (LDL) is believed to play an important role in the initiation of the atherosclerotic lesion. Dipyridamole, which is used clinically as a coronary...
3.
Selley M, McGuiness J, Bartlett M, Ardlie N
Arzneimittelforschung
. 1992 Mar;
42(3):318-21.
PMID: 1497692
Anethole dithiolthione (ADT) (10 mumol/l) inhibited platelet aggregation and the formation of thromboxane (Tx)B2 in plasma in response to adenosine diphosphate (ADP), epinephrine and arachidonic acid (AA). ADT partially inhibited...
4.
Selley M, Bartlett M, McGuiness J, Ardlie N
Chem Biol Interact
. 1990 Jan;
76(1):101-9.
PMID: 2118426
Acrolein, a component of tobacco smoke, potentiated platelet aggregation and increased thromboxane A2 (TXA2) formation caused by thrombin and arachidonic acid (AA). Acrolein produced these effects at concentrations in the...
5.
Selley M, Bartlett M, McGuiness J, Hapel A, Ardlie N
J Chromatogr
. 1989 Mar;
488(2):329-40.
PMID: 2745626
trans-4-Hydroxy-2-nonenal (HNE) is an aldehyde end-product of lipid peroxidation in biological systems which is capable of producing a range of powerful biological effects. We wish to describe a sensitive and...
6.
Selley M, McGuiness J, Jenkin L, Bartlett M, Ardlie N
Thromb Haemost
. 1988 Apr;
59(2):143-6.
PMID: 3133806
4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A2 formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at...
7.
Ardlie N, Bell L, McGuiness J
Thromb Res
. 1987 May;
46(4):519-26.
PMID: 3617010
Changes in cytoplasmic free calcium in response to epinephrine in combination with other agonists were studied in human platelets loaded with the fluorescent calcium indicator, quin 2. In the presence...
8.
Ardlie N, McGuiness J, Garrett J
Atherosclerosis
. 1985 Dec;
58(1-3):251-9.
PMID: 3004519
Epinephrine at concentrations varying between 3.3 and 12.5 nM had no effect on blood platelets when added alone, but augmented the in vitro platelet response to collagen and thrombin. Both...
9.
Ardlie N, Boatwright C, Garrett J, McGuiness J
Thromb Res
. 1985 Jun;
38(6):695-706.
PMID: 3161211
Previous reports of the inhibitory effects of trifluoperazine on platelet responses to different aggregating agents have been conflicting, and the mechanism of action remains unclear. We have found that aggregation...