J A Kleinschmidt
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Explore the profile of J A Kleinschmidt including associated specialties, affiliations and a list of published articles.
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59
Citations
2681
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Recent Articles
11.
Kronenberg S, Kleinschmidt J, Bottcher B
EMBO Rep
. 2001 Nov;
2(11):997-1002.
PMID: 11713191
Adeno-associated virus type 2 empty capsids are composed of three proteins, VP1, VP2 and VP3, which have relative molecular masses of 87, 72 and 62 kDa, respectively, and differ in...
12.
Leder C, Kleinschmidt J, WIETHE C, Muller M
J Virol
. 2001 Sep;
75(19):9201-9.
PMID: 11533183
Expression of the structural proteins L1 and L2 of the human papillomaviruses (HPV) is tightly regulated. As a consequence, attempts to express these prime-candidate genes for prophylactic vaccination against papillomavirus-associated...
13.
Jiang S, Altmann A, Grimm D, Kleinschmidt J, Schilling T, Germann C, et al.
Cancer Gene Ther
. 2001 Aug;
8(7):469-72.
PMID: 11498767
Calcitonin (CT), the major secretory product of the C cell, is also expressed in C-cell-derived neoplasia. To investigate the role of the CT gene regulatory sequence in tissue-specific gene expression,...
14.
King J, Dubielzig R, Grimm D, Kleinschmidt J
EMBO J
. 2001 Jun;
20(12):3282-91.
PMID: 11406604
Helicases not only catalyse the disruption of hydrogen bonding between complementary regions of nucleic acids, but also move along nucleic acid strands in a polar fashion. Here we show that...
15.
Wobus C, Girod A, Petersen G, Hallek M, Kleinschmidt J
J Virol
. 2000 Sep;
74(19):9281-93.
PMID: 10982375
The previously characterized monoclonal antibodies (MAbs) A1, A69, B1, and A20 are directed against assembled or nonassembled adeno-associated virus type 2 (AAV-2) capsid proteins (A. Wistuba, A. Kern, S. Weger,...
16.
Kunke D, Grimm D, Denger S, Kreuzer J, Delius H, Komitowski D, et al.
Cancer Gene Ther
. 2000 Jun;
7(5):766-77.
PMID: 10830724
Approximately 90% of cervical carcinomas are causally linked to infections with high-risk human papillomaviruses (HPVs), whose oncogenicity has been assigned to the continued expression of two early genes, E6 and...
17.
Veldwijk M, Fruehauf S, Schiedlmeier B, Kleinschmidt J, Zeller W
Cancer Gene Ther
. 2000 May;
7(4):597-604.
PMID: 10811478
The use of autologous hematopoietic stem cell (HSC) grafts after high-dose chemotherapy protocols may be hampered by contamination of the grafts with tumor cells. Because epithelial cells seem to be...
18.
Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use
Grimm D, Kleinschmidt J
Hum Gene Ther
. 1999 Oct;
10(15):2445-50.
PMID: 10543610
Vectors derived from the human parvovirus AAV-2 (adeno-associated virus type 2) are among the most promising gene delivery vehicles currently being developed. These vectors are not only capable of transducing...
19.
Veldwijk M, Schiedlmeier B, Kleinschmidt J, Zeller W, Fruehauf S
Eur J Cancer
. 1999 Oct;
35(7):1136-42.
PMID: 10533460
Autologous peripheral blood progenitor cell (PBPC) grafts can be contaminated with tumour cells that potentially give rise to relapse following myeloablative therapy and PBPC transplantation. Adeno-associated virus (AAV)-based vectors produced...
20.
Dubielzig R, King J, Weger S, Kern A, Kleinschmidt J
J Virol
. 1999 Oct;
73(11):8989-98.
PMID: 10516005
The nonstructural adeno-associated virus type 2 Rep proteins are known to control viral replication and thus provide the single-stranded DNA genomes required for packaging into preformed capsids. In addition, complexes...