J A Gegner
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Explore the profile of J A Gegner including associated specialties, affiliations and a list of published articles.
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7
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560
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Recent Articles
1.
Tobias P, Tapping R, Gegner J
Clin Infect Dis
. 1999 Apr;
28(3):476-81.
PMID: 10194064
Recent work has identified two proteins that work together to enable many cell types to respond to endotoxin. These two proteins, lipopolysaccharide (LPS) binding protein (LBP) and CD14, also participate...
2.
Tapping R, Gegner J, Kravchenko V, Tobias P
Prog Clin Biol Res
. 1998 May;
397:73-8.
PMID: 9575548
Roles for LBP and CD14 in the LPS dependent activation of a wide variety of cells have been established. In the work described here, we describe roles for these proteins...
3.
Jiang Y, Chen C, Li Z, Guo W, Gegner J, Lin S, et al.
J Biol Chem
. 1996 Jul;
271(30):17920-6.
PMID: 8663524
Mitogen-activated protein (MAP) kinase cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses. Four MAP kinase subgroups have been identified...
4.
Tobias P, Soldau K, Gegner J, Mintz D, Ulevitch R
J Biol Chem
. 1995 May;
270(18):10482-8.
PMID: 7537731
Endotoxin (lipopolysaccharide; LPS) activates a wide variety of host defense mechanisms. In mammals LPS binding protein (LBP) and CD14 interact with LPS to mediate cellular activation. Using sucrose density gradients...
5.
Gegner J, Ulevitch R, Tobias P
J Biol Chem
. 1995 Mar;
270(10):5320-5.
PMID: 7534294
Under physiological conditions, lipopolysaccharide (LPS) activation of cells involves the LPS binding protein (LBP) and either membrane or soluble CD14. We find LPS forms a ternary complex with LBP and...
6.
Gegner J, Graham D, ROTH A, Dahlquist F
Cell
. 1992 Sep;
70(6):975-82.
PMID: 1326408
We examined the binding interactions of the methylation-dependent chemotaxis receptors Tsr and Tar with the chemotaxis-specific protein kinase CheA and the coupling factor CheW. Receptor directly bound CheW, but receptor-CheA...
7.
Gegner J, Dahlquist F
Proc Natl Acad Sci U S A
. 1991 Feb;
88(3):750-4.
PMID: 1992467
An essential step in the signal transduction pathway of Escherichia coli is the control of the protein kinase activity of CheA by the chemotaxis receptor proteins. This control requires the...