J A Alhadeff
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Explore the profile of J A Alhadeff including associated specialties, affiliations and a list of published articles.
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92
Citations
348
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Recent Articles
1.
Riley L, Lange M, Browne R, Cochrane P, Choi I, Davis B, et al.
Breast Cancer Res Treat
. 2000 Jun;
60(2):173-9.
PMID: 10845280
The relative amounts of the precursor (52 kDa) and processed (31,27 kDa) forms of cathepsin D have been analyzed by Western blotting in biopsied breast tissue cytosols from 134 lesions...
2.
Alhadeff J, Khunsook S, Choowongkomon K, Baney T, Heredia V, Tweedie A, et al.
Mol Hum Reprod
. 1999 Aug;
5(9):809-15.
PMID: 10460218
Human semen contains a large amount of alpha-L-fucosidase activity, the great majority of which is found in the seminal fluid. Immunocytochemical studies indicate that a small amount of semen fucosidase...
3.
Bazel S, Alhadeff J
Int J Oncol
. 1999 Jan;
14(2):315-9.
PMID: 9917508
The aspartyl protease cathepsin D (EC 3.4.23.5) appears to be found in increased amounts and/or abnormally secreted in breast cancer cells, and may contribute to the metastatic spread of malignancy....
4.
Abascal I, Skalaban S, Grimm K, Aviles M, Castells M, Ballesta J, et al.
Biochem J
. 1998 Jun;
333 ( Pt 1):201-7.
PMID: 9639580
In a previous study, evidence was provided for the presence of a novel plasma-membrane-associated neutral-pH-optimum alpha-L-fucosidase in rat sperm. In the present study, rat sperm alpha-L-fucosidase was characterized during epididymal...
5.
Wright L, LEVY E, Patel N, Alhadeff J
J Protein Chem
. 1997 Apr;
16(3):171-81.
PMID: 9155088
The lysosomal aspartyl protease cathepsin D is present in most mammalian cells and is active in the catabolism of intracellular and endocytosed proteins. It appears to be overexpressed and abnormally...
6.
Aviles M, Abascal I, Castells M, Skalaban S, Ballesta J, Alhadeff J
Biochem J
. 1996 Sep;
318 ( Pt 3):821-31.
PMID: 8836125
1. Immunocytochemical and biochemical techniques have been used to localize and characterize a novel plasma membrane-associated, neutral-pH-optimum alpha-L-fucosidase from rat spermatozoa. Light and electron microscopy specifically localized the fucosidase on...
7.
Coronel E, Lange M, Tachovsky T, Longo S, Tucker S, Alhadeff J
Breast Cancer Res Treat
. 1995 Aug;
35(2):211-20.
PMID: 7647343
Cathepsin D from normal (Hs578Bst) and malignant (MCF7, MDA-MB-231) breast cell lines has been characterized with regard to its kinetic properties, activity levels, precursor and processed M(r) forms, and isoform...
8.
Shoarinejad F, Zhu J, Bazel S, Alhadeff J
Arch Biochem Biophys
. 1994 Jul;
312(1):173-9.
PMID: 8031125
The subunits of human liver alpha-L-fucosidase have been separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, excised, and subjected to peptide mapping after CNBr cleavage or trypsin digestion. The CNBr peptide...
9.
Ip C, MILLER W, Silberklang M, Mark G, Ellis R, Huang L, et al.
Arch Biochem Biophys
. 1994 Feb;
308(2):387-99.
PMID: 7906504
This study characterized the N-glycans of a humanized immunoglobulin G4 (IgG4) expressed in NS/O mouse myeloma cells and directed against the CD18 family of adhesion-promoting receptors on leukocytes. The N-glycans...
10.
Schultz D, Bazel S, Wright L, Tucker S, Lange M, Tachovsky T, et al.
Cancer Res
. 1994 Jan;
54(1):48-54.
PMID: 8261461
Increased total antigen amounts of cathepsin D in breast tissue have been reported to be associated with increased disease recurrence, more frequent metastasis, and increased mortality in breast cancer patients....