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Ivy Low

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Articles 12
Citations 1831
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Recent Articles
1.
Shin Park D, Kozaki T, Tiwari S, Moreira M, Khalilnezhad A, Torta F, et al.
Nature . 2023 Nov; 623(7986):397-405. PMID: 37914940
Microglia are specialized brain-resident macrophages that arise from primitive macrophages colonizing the embryonic brain. Microglia contribute to multiple aspects of brain development, but their precise roles in the early human...
2.
Strickland M, Lee S, Neo S, Balachander A, Low I, Mustafah S, et al.
Biology (Basel) . 2023 Apr; 12(4). PMID: 37106796
Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with...
3.
Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, et al.
Immunity . 2021 Sep; 54(9):2101-2116.e6. PMID: 34469775
Tissue macrophages are immune cells whose phenotypes and functions are dictated by origin and niches. However, tissues are complex environments, and macrophage heterogeneity within the same organ has been overlooked...
4.
Takata K, Kozaki T, Lee C, Thion M, Otsuka M, Lim S, et al.
Immunity . 2020 Feb; 52(2):417-418. PMID: 32075730
No abstract available.
5.
Dress R, Dutertre C, Giladi A, Schlitzer A, Low I, Shadan N, et al.
Nat Immunol . 2019 Jun; 20(7):852-864. PMID: 31213723
Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic analysis, mass cytometry, in vivo fate mapping and in vitro...
6.
Takata K, Kozaki T, Lee C, Thion M, Otsuka M, Lim S, et al.
Immunity . 2017 Jul; 47(1):183-198.e6. PMID: 28723550
Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived...
7.
McGovern N, Shin A, Low G, Low D, Duan K, Yao L, et al.
Nature . 2017 Jun; 546(7660):662-666. PMID: 28614294
During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and...
8.
See P, Dutertre C, Chen J, Gunther P, McGovern N, Irac S, et al.
Science . 2017 May; 356(6342). PMID: 28473638
Dendritic cells (DC) are professional antigen-presenting cells that orchestrate immune responses. The human DC population comprises two main functionally specialized lineages, whose origins and differentiation pathways remain incompletely defined. Here,...
9.
Guilliams M, Dutertre C, Scott C, McGovern N, Sichien D, Chakarov S, et al.
Immunity . 2016 Sep; 45(3):669-684. PMID: 27637149
Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic potential. Multiple DC subsets have been described, and it remains challenging to align them across tissues and species to...
10.
Hoeffel G, Chen J, Lavin Y, Low D, Almeida F, See P, et al.
Immunity . 2015 Apr; 42(4):665-78. PMID: 25902481
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult...