Ivraym B Barsoum
Overview
Explore the profile of Ivraym B Barsoum including associated specialties, affiliations and a list of published articles.
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9
Citations
803
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Recent Articles
1.
Kim J, Barsoum I, Loh H, Pare J, Siemens D, Graham C
Biosci Rep
. 2020 Jan;
40(1).
PMID: 31912870
A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of...
2.
Black M, Barsoum I, Truesdell P, Cotechini T, Macdonald-Goodfellow S, Petroff M, et al.
Oncotarget
. 2016 Feb;
7(9):10557-67.
PMID: 26859684
The ability of tumor cells to avoid immune destruction (immune escape) as well as their acquired resistance to anti-cancer drugs constitute important barriers to the successful management of cancer. Interaction...
3.
Barsoum I, Koti M, Siemens D, Graham C
Cancer Res
. 2014 Oct;
74(24):7185-90.
PMID: 25344227
An important aspect of malignant progression is the acquired ability of tumor cells to avoid recognition and destruction by the immune system (immune escape). Clinical cancer progression is also associated...
4.
Barsoum I, Smallwood C, Siemens D, Graham C
Cancer Res
. 2013 Dec;
74(3):665-74.
PMID: 24336068
Immune escape is a fundamental trait of cancer in which mechanistic knowledge is incomplete. Here, we describe a novel mechanism by which hypoxia contributes to tumoral immune escape from cytotoxic...
5.
Barsoum I, Kaur J, Ge R, Cooke P, Hung-Chang Yao H
FASEB J
. 2013 Apr;
27(7):2657-66.
PMID: 23568777
Testes contain two distinct Leydig cell populations during development: fetal and adult Leydig cells (FLCs and ALCs, respectively). ALCs are not derived from FLCs, and it is unknown whether these...
6.
Barsoum I, Hamilton T, Li X, Cotechini T, Miles E, Siemens D, et al.
Cancer Res
. 2011 Oct;
71(24):7433-41.
PMID: 22006996
One key to malignant progression is the acquired ability of tumor cells to escape immune-mediated lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and...
7.
Barsoum I, Renaud S, Graham C
Am J Pathol
. 2011 Jun;
178(6):2888-96.
PMID: 21641407
Preeclampsia is associated with increased circulating levels of proinflammatory molecules, such as soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng). On release by an inadequately perfused placenta into...
8.
Barsoum I, Yao H
J Androl
. 2009 Oct;
31(1):11-5.
PMID: 19875489
In most eutherian mammals, sexually dimorphic masculinization is established by androgen-producing fetal Leydig cells in the embryonic testis. Fetal Leydig cells, which lack expression of the testis-determining gene SRY, arise...
9.
Barsoum I, Bingham N, Parker K, Jorgensen J, Yao H
Dev Biol
. 2009 Mar;
329(1):96-103.
PMID: 19268447
Proper cell fate determination in mammalian gonads is critical for the establishment of sexual identity. The Hedgehog (Hh) pathway has been implicated in cell fate decision for various organs, including...