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Ivan V Kulakovskiy

Explore the profile of Ivan V Kulakovskiy including associated specialties, affiliations and a list of published articles. Areas
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Articles 70
Citations 2903
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Recent Articles
1.
Buyan A, Meshcheryakov G, Safronov V, Abramov S, Boytsov A, Nozdrin V, et al.
Nat Commun . 2025 Feb; 16(1):1739. PMID: 39966391
High-throughput sequencing facilitates large-scale studies of gene regulation and allows tracing the associations of individual genomic variants with changes in gene regulation and expression. Compared to classic association studies, the...
2.
Agarwal V, Inoue F, Schubach M, Penzar D, Martin B, Dash P, et al.
Nature . 2025 Jan; 639(8054):411-420. PMID: 39814889
The human genome contains millions of candidate cis-regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states. However, we lack a functional understanding of the sequence...
3.
Khoroshkin M, Zinkevich A, Aristova E, Yousefi H, Lee S, Mittmann T, et al.
bioRxiv . 2025 Jan; PMID: 39803435
mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains a challenge. To address this,...
4.
Jolma A, Laverty K, Fathi A, Yang A, Yellan I, Vorontsov I, et al.
bioRxiv . 2024 Nov; PMID: 39605729
We describe an effort ("Codebook") to determine the sequence specificity of 332 putative and largely uncharacterized human transcription factors (TFs), as well as 61 control TFs. Nearly 5,000 independent experiments...
5.
Vorontsov I, Kozin I, Abramov S, Boytsov A, Jolma A, Albu M, et al.
bioRxiv . 2024 Nov; PMID: 39605530
A DNA sequence pattern, or "motif", is an essential representation of DNA-binding specificity of a transcription factor (TF). Any particular motif model has potential flaws due to shortcomings of the...
6.
Gralak A, Faltejskova K, Yang A, Steiner C, Russeil J, Grenningloh N, et al.
bioRxiv . 2024 Nov; PMID: 39605503
Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assayed 284 mostly poorly characterized, putative human TFs...
7.
Jolma A, Hernandez-Corchado A, Yang A, Fathi A, Laverty K, Brechalov A, et al.
bioRxiv . 2024 Nov; PMID: 39605368
A long-standing challenge in human regulatory genomics is that transcription factor (TF) DNA-binding motifs are short and degenerate, while the genome is large. Motif scans therefore produce many false-positive binding...
8.
Razavi R, Fathi A, Yellan I, Brechalov A, Laverty K, Jolma A, et al.
bioRxiv . 2024 Nov; PMID: 39605320
Most of the human genome is thought to be non-functional, and includes large segments often referred to as "dark matter" DNA. The genome also encodes hundreds of putative and poorly...
9.
Eliseeva I, Ryazanova L, Ledova L, Zvonarev A, Valiakhmetov A, Suntsova M, et al.
J Fungi (Basel) . 2024 Nov; 10(11). PMID: 39590716
Inorganic polyphosphates and respective metabolic pathways and enzymes are important factors for yeast active growth in unfavorable conditions. However, particular proteins of polyphosphate metabolism remain poorly explored in this context....
10.
Khoroshkin M, Buyan A, Dodel M, Navickas A, Yu J, Trejo F, et al.
Nat Commun . 2024 Oct; 15(1):9277. PMID: 39468017
No abstract available.