Ivan Mikicic
Overview
Explore the profile of Ivan Mikicic including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
125
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Recent Articles
1.
Papadopoulos D, Ha S, Fleischhauer D, Uhl L, Russell T, Mikicic I, et al.
Mol Cell
. 2024 May;
84(11):2070-2086.e20.
PMID: 38703770
The MYCN oncoprotein binds active promoters in a heterodimer with its partner protein MAX. MYCN also interacts with the nuclear exosome, a 3'-5' exoribonuclease complex, suggesting a function in RNA...
2.
Bhatia P, Bickle M, Agrawal A, Truss B, Nikolaidi A, Brockmann K, et al.
Biology (Basel)
. 2024 Jan;
13(1).
PMID: 38275734
The degeneration of axon terminals before the soma, referred to as "dying back", is a feature of Parkinson's disease (PD). Axonal assays are needed to model early PD pathogenesis as...
3.
Suryo Rahmanto A, Blum C, Scalera C, Heidelberger J, Mesitov M, Horn-Ghetko D, et al.
Mol Cell
. 2023 Nov;
83(23):4272-4289.e10.
PMID: 37951215
Reactive aldehydes are produced by normal cellular metabolism or after alcohol consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are impaired. Their toxicity has been attributed to...
4.
Stier A, Gilberto S, Mohamed W, Royall L, Helenius J, Mikicic I, et al.
EMBO J
. 2023 Jun;
42(17):e112847.
PMID: 37365982
The paralogs CUL4A and CUL4B assemble cullin-RING E3 ubiquitin ligase (CRL) complexes regulating multiple chromatin-associated cellular functions. Although they are structurally similar, we found that the unique N-terminal extension of...
5.
Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, et al.
Nat Commun
. 2023 Jun;
14(1):3787.
PMID: 37355687
The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in the nucleus are still controversial. Here we show that the...
6.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, et al.
Nature
. 2022 Nov;
612(7938):148-155.
PMID: 36424410
Oncoproteins of the MYC family drive the development of numerous human tumours. In unperturbed cells, MYC proteins bind to nearly all active promoters and control transcription by RNA polymerase II....
7.
Mosler T, Baymaz H, Graf J, Mikicic I, Blattner G, Bartlett E, et al.
Nucleic Acids Res
. 2022 Nov;
50(20):11600-11618.
PMID: 36350633
PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient breast, ovarian, and prostate cancer. Loss...
8.
Graf J, Mikicic I, Ping X, Scalera C, Mayr K, Stelzl L, et al.
iScience
. 2022 Sep;
25(9):104892.
PMID: 36060052
PPM1D is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) and is frequently altered in cancer. Here, we employed chemical inhibition of PPM1D and quantitative mass spectrometry-based...
9.
Wegmann S, Meister C, Renz C, Yakoub G, Wollscheid H, Takahashi D, et al.
Mol Cell
. 2022 Mar;
82(8):1589-1602.e5.
PMID: 35263628
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is...
10.
Mosler T, Conte F, Longo G, Mikicic I, Kreim N, Mockel M, et al.
Nat Commun
. 2021 Dec;
12(1):7314.
PMID: 34916496
Transcription poses a threat to genomic stability through the formation of R-loops that can obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures formed by an RNA-DNA hybrid...