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Ivan Koychev

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Articles 74
Citations 1088
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Recent Articles
1.
De Giorgi R, Koychev I, Adler A, Cowen P, Harmer C, Harrison P, et al.
EClinicalMedicine . 2025 Jan; 74:102726. PMID: 39764175
Background: While semaglutide, approved for type-2 diabetes mellitus (T2DM), is being investigated as a treatment for brain disorders, concerns over adverse neuropsychiatric events have emerged. More data are therefore needed...
2.
Buller-Peralta I, Gregory S, Low A, Dounavi M, Bridgeman K, Ntailianis G, et al.
Front Hum Neurosci . 2025 Jan; 18:1509223. PMID: 39758685
Objectives: We assessed the modulation of allostatic load (AL) by engagement in healthy habits and life stressors, mediated through resilience and the perceived influence of the stressors. Sleep was included...
3.
Rowland H, Miller G, Liu Q, Li S, Sharp N, Ng B, et al.
Stem Cells . 2024 Dec; 43(3). PMID: 39704342
Human induced pluripotent stem cells (iPSCs) provide powerful cellular models of Alzheimer's disease (AD) and offer many advantages over non-human models, including the potential to reflect variation in individual-specific pathophysiology...
4.
Stefaniak J, Mak E, Su L, Carter S, Dounavi M, Terrera G, et al.
Brain Commun . 2024 Nov; 6(6):fcae392. PMID: 39605972
Brain Age Gap has been associated with dementia in old age. Less is known relating brain age gap to dementia risk-factors or cognitive performance in middle-age. Cognitively healthy, middle-aged subjects...
5.
Qi Q, Deng F, Sammon R, Ritchie K, Muniz-Terrera G, Koychev I, et al.
Alzheimers Res Ther . 2024 Nov; 16(1):246. PMID: 39533372
Background: Females have a higher age-adjusted incidence of Alzheimer's Disease (AD) than males, even when accounting for longer lifespan and, therefore, stand to benefit the most from dementia prevention efforts....
6.
Al-Diwani A, Provine N, Murchison A, Laban R, Swann O, Koychev I, et al.
Brain . 2024 Oct; 148(2):394-400. PMID: 39432679
In animal models, brain neurodegeneration biomarkers drain into cervical lymph nodes (CLNs), and this drainage function is reduced with ageing. If this occurred in humans, CLNs may provide a readily...
7.
Sen A, Toniolo S, Tai X, Akinola M, Symmonds M, Mura S, et al.
Epilepsia Open . 2024 Oct; 9(6):2353-2364. PMID: 39400461
Objective: To assess whether the antiseizure medication levetiracetam may improve cognition in individuals with Alzheimer's disease who have not previously experienced a seizure. Methods: We performed a randomized, double-blind, placebo-controlled...
8.
Koychev I, Reid G, Nguyen M, Mentz R, Joyce D, Shah S, et al.
Alzheimers Res Ther . 2024 Oct; 16(1):212. PMID: 39358806
Background: Glucagon-like peptide-1 receptor agonists are a viable option for the prevention of Alzheimer's disease (AD) but the mechanisms of this potential disease modifying action are unclear. We investigated the...
9.
Vassileva S, Grazhdanski G, Koychev I, Boytcheva S
Database (Oxford) . 2024 Sep; 2024. PMID: 39259689
This paper presents a transformer-based approach for symptom Named Entity Recognition (NER) in Spanish clinical texts and multilingual entity linking on the SympTEMIST dataset. For Spanish NER, we fine tune...
10.
Low A, McKiernan E, Prats-Sedano M, Carter S, Stefaniak J, Su L, et al.
JAMA Netw Open . 2024 Aug; 7(8):e2426774. PMID: 39145979
Importance: Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in...