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Ivan Bravo

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Articles 55
Citations 293
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Recent Articles
1.
Ocana A, Pandiella A, Privat C, Bravo I, Luengo-Oroz M, Amir E, et al.
Biomark Res . 2025 Mar; 13(1):45. PMID: 40087789
Artificial intelligence (AI) can transform drug discovery and early drug development by addressing inefficiencies in traditional methods, which often face high costs, long timelines, and low success rates. In this...
2.
Herrera-Ochoa D, Bravo I, Garzon-Ruiz A
Colloids Surf B Biointerfaces . 2024 Sep; 245:114265. PMID: 39321721
Anticancer therapies with cisplatin and volasertib (BI-6727) were monitored by fluorescence lifetime imaging microscopy (FLIM) in live SK-Mel-2 melanoma cells. A CdSe/ZnS quantum dot functionalized with a peptide containing D-penicillamine...
3.
Diaz-Tejeiro C, Arenas-Moreira M, Sanvicente A, Paniagua-Herranz L, Clemente-Casares P, Bravo I, et al.
Biomed Pharmacother . 2024 Jul; 178:117165. PMID: 39059354
Colorectal cancer (CRC) is the third most common cancer worldwide. Recent experiments suggest that CDK12 can be a good therapeutic target in CRC, and therefore, novel inhibitors targeting this protein...
4.
Fernandez-Sainz J, Herrera-Ochoa D, Pacheco-Linan P, Darder M, Albaladejo J, Bravo I, et al.
Spectrochim Acta A Mol Biomol Spectrosc . 2024 Jul; 322:124823. PMID: 39033609
In the present work, we study different physicochemical properties related to LADME processes of volasertib, a Polo-like kinase 1 inhibitor in advanced clinical trials. Firstly, the protonation equilibria, the extent...
5.
Herrera-Ochoa D, Llano I, Ripoll C, Cybulski P, Kreuzer M, Rocha S, et al.
J Mater Chem B . 2024 Jul; 12(31):7577-7590. PMID: 38984432
The development of new fluorescent probes as molecular sensors is a critical step for the understanding of molecular mechanisms. BODIPY-based probes offer versatility due to their high fluorescence quantum yields,...
6.
Ripoll C, Del Campo-Balguerias A, Alonso-Moreno C, Herrera-Ochoa D, Ocana A, Martin C, et al.
J Colloid Interface Sci . 2024 Jun; 674:186-193. PMID: 38925064
The effective measurement of temperature in living systems at the nano and microscopic scales continues to be a challenge to this day. Here, we study the use of 2-(anthracen-2-yl)-1,3-diisopropylguanidine, 1,...
7.
Parra-Cadenas B, Bravo I, Ripoll Lorente M, Gines C, Elorriaga D, Carrillo-Hermosilla F
Inorg Chem . 2024 Jun; 63(26):12120-12132. PMID: 38873888
Two series of boron derivatives with propiolamidinato ligands, [BPh{C(C≡CAr)(NR)}] (Ar = Ph, -MeOPh, -FPh, -MeNPh, or phen; R = iPr or -tolyl), were synthesized and structurally characterized. The corresponding propiolamidine...
8.
Dominguez-Jurado E, Ripoll C, Lara-Sanchez A, Ocana A, Vitorica-Yrezabal I, Bravo I, et al.
J Inorg Biochem . 2024 Jan; 253:112486. PMID: 38266323
The modular synthesis of the heteroscorpionate core is explored as a tool for the rapid development of ruthenium-based therapeutic agents. Starting with a series of structurally diverse alcohol-NN ligands, a...
9.
Del Campo-Balguerias A, Parra-Cadenas B, Nieto-Jimenez C, Bravo I, Ripoll C, Poyatos-Racionero E, et al.
Int J Mol Sci . 2023 Sep; 24(18). PMID: 37762123
The modular synthesis of the guanidine core by guanylation reactions using commercially available ZnEt as a catalyst has been exploited as a tool for the rapid development of antitumoral guanidine...
10.
Pacheco-Linan P, Alonso-Moreno C, Ocana A, Ripoll C, Garcia-Gil E, Garzon-Ruiz A, et al.
ACS Appl Mater Interfaces . 2023 Sep; 15(38):44786-44795. PMID: 37699547
AIEgens have emerged as a promising alternative to molecular rotors in bioimaging applications. However, transferring the concept of aggregation-induced emission (AIE) from solution to living systems remains a challenge. Given...