Ivan A Borbon
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Explore the profile of Ivan A Borbon including associated specialties, affiliations and a list of published articles.
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9
Citations
154
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Recent Articles
1.
Erickson R, Borbon I
J Appl Genet
. 2019 Mar;
60(2):175-178.
PMID: 30815842
We previously reported the altered pulmonary function and pathology found in the mouse model of infantile Niemann-Pick C1 disease, the Npc1 mouse. Despite its salutary properties on brain and liver...
2.
Marshall C, Borbon I, Erickson R
J Appl Genet
. 2016 Oct;
58(1):99-102.
PMID: 27783333
Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 / Npc1 mouse model of infantile NPC1 disease....
3.
Deutsch G, Muralidhar A, Le E, Borbon I, Erickson R
Gene
. 2015 Dec;
578(2):242-50.
PMID: 26707209
We have studied the pathophysiology of lung disease which occurs in two mouse models of Niemann-Pick C1 disease. We utilized Npc1(-/-) mice transgenic for normal gene expression in glia or...
4.
Borbon I, Hillman Z, Duran Jr E, Kiela P, Frautschy S, Erickson R
Pharmacol Biochem Behav
. 2011 Dec;
101(1):125-31.
PMID: 22202649
In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable...
5.
Maue R, Burgess R, Wang B, Wooley C, Seburn K, Vanier M, et al.
Hum Mol Genet
. 2011 Nov;
21(4):730-50.
PMID: 22048958
We have identified a point mutation in Npc1 that creates a novel mouse model (Npc1(nmf164)) of Niemann-Pick type C1 (NPC) disease: a single nucleotide change (A to G at cDNA...
6.
Totenhagen J, Lope-Piedrafita S, Borbon I, Yoshimaru E, Erickson R, Trouard T
J Magn Reson Imaging
. 2011 Nov;
35(3):528-36.
PMID: 22045516
Purpose: To quantitatively and noninvasively assess neurological disease progression in a mouse model of Niemann-Pick type C (NPC) disease by measuring white matter status with magnetic resonance imaging (MRI) techniques...
7.
Jelinek D, Maghsoodi B, Borbon I, Hardwick R, Cherrington N, Erickson R
Gene
. 2011 Oct;
491(2):128-34.
PMID: 22020183
We have previously shown that male Npc1 heterozygous mice (Npc1(+/-)), as compared to homozygous wild-type mice (Npc1(+/+)), both maintained on the "lean" BALB/cJ genetic background, become obese on a high...
8.
Muralidhar A, Borbon I, Esharif D, Ke W, Manacheril R, Daines M, et al.
Mol Genet Metab
. 2011 Apr;
103(2):142-7.
PMID: 21459030
Lung dysfunction is an important part of the pathology of the neurodegenerative disorder, Niemann-Pick C1 (NPC1). We have studied the pulmonary disease in the Npc1(NIH/NIH) mouse model. On histology, we...
9.
Borbon I, Erickson R
J Appl Genet
. 2010 Dec;
52(2):213-8.
PMID: 21170692
Although Niemann-Pick C1 disease has frequently been called "juvenile Alzheimer's", the effects of introducing Npc1 mutations into a mouse model of Alzheimer's have not previously been performed. We have crossed...