Israel Steinfeld
Overview
Explore the profile of Israel Steinfeld including associated specialties, affiliations and a list of published articles.
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24
Citations
3953
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Recent Articles
1.
Ryan D, Diamant-Levi T, Steinfeld I, Taussig D, Visal-Shah S, Thakker S, et al.
Biochemistry
. 2022 Apr;
62(24):3512-3520.
PMID: 35436085
CRISPR gene editing and control systems continue to emerge and inspire novel research and clinical applications. Advances in CRISPR performance such as optimizing the duration of activity in cells, tissues,...
2.
Cromer M, Vaidyanathan S, Ryan D, Curry B, Bergstrom Lucas A, Camarena J, et al.
Mol Ther
. 2018 Jul;
26(10):2431-2442.
PMID: 30005866
Genome-editing technologies are currently being translated to the clinic. However, cellular effects of the editing machinery have yet to be fully elucidated. Here, we performed global microarray-based gene expression measurements...
3.
Ryan D, Taussig D, Steinfeld I, Phadnis S, Lunstad B, Singh M, et al.
Nucleic Acids Res
. 2017 Dec;
46(2):792-803.
PMID: 29216382
CRISPR systems have emerged as transformative tools for altering genomes in living cells with unprecedented ease, inspiring keen interest in increasing their specificity for perfectly matched targets. We have developed...
4.
Haakensen V, Steinfeld I, Saldova R, Asadi Shehni A, Kifer I, Naume B, et al.
Mol Oncol
. 2015 Sep;
10(1):59-72.
PMID: 26321095
Glycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N-glycans have potential diagnostic value as cancer serum biomarkers. We have...
5.
Hendel A, Bak R, Clark J, Kennedy A, Ryan D, Roy S, et al.
Nat Biotechnol
. 2015 Jun;
33(9):985-989.
PMID: 26121415
CRISPR-Cas-mediated genome editing relies on guide RNAs that direct site-specific DNA cleavage facilitated by the Cas endonuclease. Here we report that chemical alterations to synthesized single guide RNAs (sgRNAs) enhance...
6.
Steinfeld I, Navon R, Creech M, Yakhini Z, Tsalenko A
Bioinformatics
. 2015 Jan;
31(10):1683-5.
PMID: 25577435
ENViz (Enrichment Analysis and Visualization) is a Cytoscape app that performs joint enrichment analysis of two types of sample matched datasets in the context of systematic annotations. Such datasets may...
7.
Ella E, Heim D, Stoyanov E, Harari-Steinfeld R, Steinfeld I, Pappo O, et al.
Oncotarget
. 2014 Nov;
5(21):10318-31.
PMID: 25401338
Resection of hepatocellular carcinoma (HCC) tumors by partial hepatectomy (PHx) is associated with promoting hepatocarcinogenesis. We have previously reported that PHx promotes hepatocarcinogenesis in the Mdr2-knockout (Mdr2-KO) mouse, a model...
8.
Saldova R, Asadi Shehni A, Haakensen V, Steinfeld I, Hilliard M, Kifer I, et al.
J Proteome Res
. 2014 Mar;
13(5):2314-27.
PMID: 24669823
An improved separation of the human serum N-glycome using hydrophilic interaction chromatography technology with UPLC is described, where more than 140 N-glycans were assigned. Using this technique, serum samples from...
9.
Nejman D, Straussman R, Steinfeld I, Ruvolo M, Roberts D, Yakhini Z, et al.
Cancer Res
. 2014 Jan;
74(5):1475-83.
PMID: 24453003
De novo methylation of CpG islands is seen in many cancers, but the general rules governing this process are not known. By analyzing DNA from tumors, as well as normal...
10.
Tahiri A, Leivonen S, Luders T, Steinfeld I, Aure M, Geisler J, et al.
Carcinogenesis
. 2013 Oct;
35(1):76-85.
PMID: 24104550
MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer has been thoroughly investigated,...