Isabella Rauch
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Explore the profile of Isabella Rauch including associated specialties, affiliations and a list of published articles.
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36
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1610
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Recent Articles
1.
Churchill M, Pandeya A, Bauer R, Christopher T, Krug S, Honodel R, et al.
J Exp Med
. 2025 Mar;
222(6).
PMID: 40079814
To distinguish pathogens from commensals, the intestinal epithelium employs cytosolic innate immune sensors. Activation of the NAIP-NLRC4 inflammasome initiates extrusion of infected intestinal epithelial cells (IEC) upon cytosolic bacterial sensing....
2.
Helliwell E, Rauch I, Nice T, Merritt J, Kreth J
Infect Immun
. 2025 Feb;
93(3):e0053524.
PMID: 39969179
The commensal is highly prevalent in the oral cavity and characterized for its ability to inhibit growth of oral pathogens. Like many other cell types, streptococci produce extracellular membrane vesicles...
3.
Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity
Wright A, Harris S, Madden S, Ramirez Reyes B, Mulamula E, Gibson A, et al.
Mucosal Immunol
. 2024 Apr;
17(4):633-650.
PMID: 38604478
Intestinal epithelial cell (IEC) responses to interferon (IFN) favor antiviral defense with minimal cytotoxicity, but IEC-specific factors that regulate these responses remain poorly understood. Interferon regulatory factors (IRFs) are a...
4.
Scott W, Rauch I
Methods Mol Biol
. 2023 Apr;
2641:27-36.
PMID: 37074639
Targeted activation of the NAIP-NLRC4 inflammasome has proven very useful in the study of pyroptosis. FlaTox and derivative LFn-NAIP-ligand cytosolic delivery systems offer a unique opportunity to interrogate both ligand...
5.
Naseer N, Zhang J, Bauer R, Constant D, Nice T, Brodsky I, et al.
Infect Immun
. 2022 Jun;
90(7):e0066321.
PMID: 35678562
Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that causes diseases ranging from gastroenteritis to systemic infection and sepsis. Salmonella uses type III secretion systems (T3SS) to inject effectors into...
6.
Naseer N, Egan M, Reyes Ruiz V, Scott W, Hunter E, Demissie T, et al.
PLoS Pathog
. 2022 Jan;
18(1):e1009718.
PMID: 35073381
Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that uses two distinct type III secretion systems (T3SSs), termed Salmonella pathogenicity island (SPI)-1 and SPI-2, to deliver virulence factors into the...
7.
Deets K, Nichols Doyle R, Rauch I, Vance R
Elife
. 2021 Dec;
10.
PMID: 34939932
The innate immune system detects pathogens and initiates adaptive immune responses. Inflammasomes are central components of the innate immune system, but whether inflammasomes provide sufficient signals to activate adaptive immunity...
8.
Churchill M, Mitchell P, Rauch I
J Mol Biol
. 2021 Oct;
434(4):167278.
PMID: 34627788
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases including the...
9.
Constant D, Nice T, Rauch I
Curr Opin Immunol
. 2021 Aug;
73:1-8.
PMID: 34392232
Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting, and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern recognition receptors in epithelial cells bind to...
10.
Oyesola O, Shanahan M, Kanke M, Mooney B, Webb L, Smita S, et al.
J Exp Med
. 2021 Jul;
218(9).
PMID: 34283207
Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth infection. How these epithelial responses are regulated remains incompletely understood....