Isabel Pont
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Explore the profile of Isabel Pont including associated specialties, affiliations and a list of published articles.
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10
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17
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Recent Articles
1.
Pont I, Felipe R, Frias J, Chicote J, Garcia-Espana A, Garcia-Espana E, et al.
Biomolecules
. 2024 Nov;
14(11).
PMID: 39595524
This study focuses on the development of a novel liposome-based nanodelivery system designed to encapsulate polyamine-1, a compound with potential anti-tumor properties. The main objective of this work was to...
2.
Pont I, Galiana-Rosello C, Sabater-Arcis M, Bargiela A, Frias J, Albelda M, et al.
Org Biomol Chem
. 2022 Dec;
21(5):1000-1007.
PMID: 36541358
Two new ligands (TPB3P and TPB3Py) showing a strong stabilisation effect and good selectivity for G4 over duplex DNAs have been synthesised. The ligands hold three analogous polyamine pendant arms...
3.
Delgado-Pinar E, Pont I, Garcia-Espana E, Seixas de Melo J
Phys Chem Chem Phys
. 2022 Jan;
24(4):2403-2411.
PMID: 35019912
Three ligands bearing triphenylamine as a core and one, two or three acyclic polyamine chains, TPA1p, TPA2p and TPA3p, respectively, have been studied by potentiometric and photophysical (UV-Vis, steady-state and...
4.
Rapisarda A, Bargiela A, Llamusi B, Pont I, Estrada-Tejedor R, Garcia-Espana E, et al.
Sci Rep
. 2021 Oct;
11(1):19417.
PMID: 34593893
In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and trigger...
5.
Cluster dirhenium(III) cis-dicarboxylates with α-amino acids ligands as mighty selective G4s binders
Shtemenko N, Pont I, Husak Y, Golichenko A, Blasco S, Shtemenko A, et al.
J Inorg Biochem
. 2021 Sep;
225:111605.
PMID: 34560372
The synthesis of four dirhenium(III) cis-dicarboxylates with the α-amino acids residues Asp (I), Glu (II), Phe (III) and Tyr (IV) is presented. The G-quadruplex stabilization potential was evaluated by fluorescence...
6.
Ambrosi G, Paz Clares M, Pont I, Formica M, Fusi V, Ricci A, et al.
Dalton Trans
. 2020 Jan;
49(6):1897-1906.
PMID: 31970351
A ligand comprised of a macrocyclic pyridinophane core having a pendant arm containing a secondary amine group linked through a methylene spacer to a pyridyl-oxadiazole-phenyl (PyPD) fluorescent system has been...
7.
Pont I, Martinez-Camarena A, Galiana-Rosello C, Tejero R, Albelda M, Gonzalez-Garcia J, et al.
Chembiochem
. 2019 Nov;
21(8):1167-1177.
PMID: 31701633
Currently, significant efforts are devoted to designing small molecules able to bind selectively to guanine quadruplexes (G4s). These noncanonical DNA structures are implicated in various important biological processes and have...
8.
Pont I, Gonzalez-Garcia J, Inclan M, Reynolds M, Delgado-Pinar E, Albelda M, et al.
Chemistry
. 2018 May;
24(42):10850-10858.
PMID: 29768679
A new series of triphenylamine-based ligands with one (TPA1PY), two (TPA2PY) or three pendant aza-macrocycle(s) (TPA3PY) has been synthesised and studied by means of pH-metric titrations, UV/Vis spectroscopy and fluorescence...
9.
Pont I, Calatayud-Pascual A, Lopez-Castellano A, Albelda E, Garcia-Espana E, Marti-Bonmati L, et al.
PLoS One
. 2018 Jan;
13(1):e0190540.
PMID: 29338009
Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis...
10.
Inclan M, Guijarro L, Pont I, Frias J, Rotger C, Orvay F, et al.
Chemistry
. 2017 Aug;
23(63):15966-15973.
PMID: 28833584
The interaction of a polyazacyclophane ligand having an ethylamine pendant arm functionalized with an anthryl group (L), with the single-stranded polynucleotides polyA, polyG, polyU, and polyC as well as with...