Iris D Young
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Explore the profile of Iris D Young including associated specialties, affiliations and a list of published articles.
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32
Citations
1825
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Recent Articles
1.
Diaz R, Ecker A, Correy G, Asthana P, Young I, Faust B, et al.
Elife
. 2024 Jun;
12.
PMID: 38884443
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of...
2.
Smith N, Dasgupta M, Wych D, Dolamore C, Sierra R, Lisova S, et al.
Sci Adv
. 2024 Mar;
10(13):eadk7201.
PMID: 38536910
Enzymes populate ensembles of structures necessary for catalysis that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography at an x-ray free electron laser to observe catalysis in...
3.
Young I, Mendez D, Poon B, Blaschke J, Wittwer F, Wall M, et al.
Methods Enzymol
. 2023 Sep;
688:195-222.
PMID: 37748827
This chapter discusses the use of diffraction simulators to improve experimental outcomes in macromolecular crystallography, in particular for future experiments aimed at diffuse scattering. Consequential decisions for upcoming data collection...
4.
Wolff A, Nango E, Young I, Brewster A, Kubo M, Nomura T, et al.
Nat Chem
. 2023 Sep;
15(11):1549-1558.
PMID: 37723259
Understanding and controlling protein motion at atomic resolution is a hallmark challenge for structural biologists and protein engineers because conformational dynamics are essential for complex functions such as enzyme catalysis...
5.
Smith N, Dasgupta M, Wych D, Dolamore C, Sierra R, Lisova S, et al.
bioRxiv
. 2023 Aug;
PMID: 37645800
Enzymes populate ensembles of structures with intrinsically different catalytic proficiencies that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography (MISC) at an X-ray free electron laser (XFEL)...
6.
Diaz R, Ecker A, Correy G, Asthana P, Young I, Faust B, et al.
bioRxiv
. 2023 Jul;
PMID: 37398339
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of...
7.
Tetreau G, Sawaya M, De Zitter E, Andreeva E, Banneville A, Schibrowsky N, et al.
Nat Commun
. 2022 Jul;
13(1):4376.
PMID: 35902572
Cry11Aa and Cry11Ba are the two most potent toxins produced by mosquitocidal Bacillus thuringiensis subsp. israelensis and jegathesan, respectively. The toxins naturally crystallize within the host; however, the crystals are...
8.
Tsai K, Stojkovic V, Lee D, Young I, Szal T, Klepacki D, et al.
Nat Struct Mol Biol
. 2022 Feb;
29(2):162-171.
PMID: 35165456
The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center. Recent work has demonstrated that linezolid...
9.
Tsai K, Stojkovic V, Noda-Garcia L, Young I, Myasnikov A, Kleinman J, et al.
Elife
. 2022 Jan;
11.
PMID: 35015630
Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the...
10.
Hussein R, Ibrahim M, Bhowmick A, Simon P, Chatterjee R, Lassalle L, et al.
Nat Commun
. 2021 Nov;
12(1):6531.
PMID: 34764256
Light-driven oxidation of water to molecular oxygen is catalyzed by the oxygen-evolving complex (OEC) in Photosystem II (PS II). This multi-electron, multi-proton catalysis requires the transport of two water molecules...