Irina S-R Waisertreiger
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Explore the profile of Irina S-R Waisertreiger including associated specialties, affiliations and a list of published articles.
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4
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81
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Recent Articles
1.
Waisertreiger I, Liston V, Menezes M, Kim H, Lobachev K, Stepchenkova E, et al.
Environ Mol Mutagen
. 2012 Oct;
53(9):699-724.
PMID: 23055184
The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti-parallel...
2.
Menezes M, Waisertreiger I, Lopez-Bertoni H, Luo X, Pavlov Y
PLoS One
. 2012 Mar;
7(2):e32313.
PMID: 22384212
Pure nucleotide precursor pools are a prerequisite for high-fidelity DNA replication and the suppression of mutagenesis and carcinogenesis. ITPases are nucleoside triphosphate pyrophosphatases that clean the precursor pools of the...
3.
Lada A, Waisertreiger I, Grabow C, Prakash A, Borgstahl G, Rogozin I, et al.
PLoS One
. 2011 Sep;
6(9):e24848.
PMID: 21935481
Background: Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized...
4.
Waisertreiger I, Menezes M, Randazzo J, Pavlov Y
J Nucleic Acids
. 2010 Oct;
2010.
PMID: 20936128
Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress, inflammation, and aberrant nucleotide biosynthesis. Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e.,...