Irina Langier Goncalves
Overview
Explore the profile of Irina Langier Goncalves including associated specialties, affiliations and a list of published articles.
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6
Citations
37
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Recent Articles
1.
Achlaug L, Langier Goncalves I, Aronheim A
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38673859
The dynamic relationship between heart failure and cancer poses a dual challenge. While cardiac remodeling can promote cancer growth and metastasis, tumor development can ameliorate cardiac dysfunction and suppress fibrosis....
2.
Langier Goncalves I, Awwad L, Aviram S, Izraeli T, Achlaug L, Aronheim A
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38139195
Heart failure and cancer are currently the deadliest diseases in the Western world, posing the most pressing clinical challenges that remain unmet today. Both conditions share similar risk factors, including...
3.
Achlaug L, Awwad L, Langier Goncalves I, Goldenberg T, Aronheim A
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628775
The interplay between heart failure and cancer represents a double-edged sword. Whereas cardiac remodeling promotes cancer progression, tumor growth suppresses cardiac hypertrophy and reduces fibrosis deposition. Whether these two opposing...
4.
Shamsuzzama , Lebedev R, Trabelcy B, Langier Goncalves I, Gerchman Y, Sapir A
Curr Biol
. 2020 Jun;
30(15):3031-3038.e7.
PMID: 32559444
Cholesterol is one of the hallmarks of animals. In vertebrates, the cholesterol synthesis pathway (CSP) is the primary source of cholesterol that has numerous structural and regulative roles [1]. Nevertheless,...
5.
Langier Goncalves I, Tal S, Barki-Harrington L, Sapir A
Mol Metab
. 2020 Apr;
39:101003.
PMID: 32339771
Objective: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins...
6.
Oks O, Lewin S, Langier Goncalves I, Sapir A
Genetics
. 2018 Mar;
209(2):457-473.
PMID: 29599115
The mevalonate pathway is the primary target of the cholesterol-lowering drugs statins, some of the most widely prescribed medicines of all time. The pathway's enzymes not only catalyze the synthesis...