Irene Georgakoudi
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Explore the profile of Irene Georgakoudi including associated specialties, affiliations and a list of published articles.
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Articles
131
Citations
3268
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Recent Articles
1.
Zhang Y, Savvidou M, Liaudanskaya V, Singh P, Fu Y, Nasreen A, et al.
Sci Adv
. 2024 Dec;
10(50):eadp1980.
PMID: 39661671
Neuron-glial cell interactions following traumatic brain injury (TBI) determine the propagation of damage and long-term neurodegeneration. Spatiotemporally heterogeneous cytosolic and mitochondrial metabolic pathways are involved, leading to challenges in developing...
2.
Zhang Y, Savvidou M, Liaudanskaya V, Ramanathan V, Bui T, Matthew L, et al.
bioRxiv
. 2024 Aug;
PMID: 39211249
Brain metabolism is essential for the function of organisms. While established imaging methods provide valuable insights into brain metabolic function, they lack the resolution to capture important metabolic interactions and...
3.
Camli B, Andrus L, Roy A, Mishra B, Xu C, Georgakoudi I, et al.
Biomed Opt Express
. 2024 Jun;
15(5):3163-3182.
PMID: 38855663
In this paper, we present a 2-photon imaging probe system featuring a novel fluorescence collection method with improved and reliable efficiency. The system aims to miniaturize the potential of 2-photon...
4.
Polleys C, Singh P, Thieu H, Genega E, Jahanseir N, Zuckerman A, et al.
bioRxiv
. 2024 May;
PMID: 38798665
Purpose: Two-photon microscopy (2PM) is an emerging clinical imaging modality with the potential to non-invasively assess tissue metabolism and morphology in high-resolution. This study aimed to assess the translational potential...
5.
Bonora M, Morganti C, van Gastel N, Ito K, Calura E, Zanolla I, et al.
Cell Stem Cell
. 2024 Mar;
31(3):359-377.e10.
PMID: 38458178
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within...
6.
Vora N, Shekar P, Hanulia T, Esmail M, Patra A, Georgakoudi I
Lab Chip
. 2024 Mar;
24(8):2237-2252.
PMID: 38456773
Metastatic tumors have poor prognoses for progression-free and overall survival for all cancer patients. Rare circulating tumor cells (CTCs) and rarer circulating tumor cell clusters (CTCCs) are potential biomarkers of...
7.
Vora N, Polleys C, Sakellariou F, Georgalis G, Thieu H, Genega E, et al.
J Biomed Opt
. 2023 Dec;
28(12):126006.
PMID: 38144697
Significance: Label-free, two-photon excited fluorescence (TPEF) imaging captures morphological and functional metabolic tissue changes and enables enhanced understanding of numerous diseases. However, noise and other artifacts present in these images...
8.
Singh P, Ramanathan V, Zhang Y, Georgakoudi I, Jay D
Cancers (Basel)
. 2023 Nov;
15(21).
PMID: 37958410
Cancer cell-secreted eHsp90 binds and activates proteins in the tumor microenvironment crucial in cancer invasion. Therefore, targeting eHsp90 could inhibit invasion, preventing metastasis-the leading cause of cancer-related mortality. Previous eHsp90...
9.
Shiu J, Lentsch G, Polleys C, Mobasher P, Ericson M, Georgakoudi I, et al.
J Invest Dermatol
. 2023 Nov;
144(4):912-915.e2.
PMID: 37952609
No abstract available.
10.
Sanchez-Hernandez A, Polleys C, Georgakoudi I
Biomed Opt Express
. 2023 Oct;
14(10):5238-5253.
PMID: 37854574
Endogenous NAD(P)H and FAD two-photon excited fluorescence (TPEF) images provide functional metabolic information with high spatial resolution for a wide range of living specimens. Preservation of metabolic function optical metrics...