Iouri Bachmakov
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Explore the profile of Iouri Bachmakov including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
114
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Recent Articles
1.
Bachmakov I, Glaeser H, Fromm M, Konig J
Diabetes
. 2008 Mar;
57(6):1463-9.
PMID: 18314419
Objective: The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies...
2.
Dragonas C, Wagner J, Heppner H, Bertsch T, Muhlberg W, Wicklein S, et al.
Eur J Clin Pharmacol
. 2007 Dec;
64(4):367-72.
PMID: 18080812
Objective: Digitoxin is a known substrate of the efflux pump P-glycoprotein (gene name: ABCB1). P-glycoprotein expression was shown to be modulated by single nucleotide polymorphisms in the ABCB1 gene, but...
3.
Eberl S, Renner B, Neubert A, Reisig M, Bachmakov I, Konig J, et al.
Clin Pharmacokinet
. 2007 Nov;
46(12):1039-49.
PMID: 18027988
Objectives: We determined in vitro the potency of macrolides as P-glycoprotein inhibitors and tested in hospitalised patients whether coadministration of P-glycoprotein inhibitors leads to increased serum concentrations of the P-glycoprotein...
4.
Fromm M, Schwilden H, Bachmakov I, Konig J, Bremer F, Schuttler J
Eur J Clin Pharmacol
. 2007 Sep;
63(12):1129-33.
PMID: 17786417
Objective: Information is lacking on whether the CYP3A5 genotype affects the disposition and effects of midazolam during the long-term intensive care sedation of patients. This study was undertaken to estimate...
5.
Bachmakov I, Werner U, Endress B, Auge D, Fromm M
Fundam Clin Pharmacol
. 2006 May;
20(3):273-82.
PMID: 16671962
Transporter proteins such as P-glycoprotein are major determinants of intracellular drug concentrations. Moreover, inhibition or induction of transporters is an important mechanism underlying drug interactions in humans. However, very little...
6.
Cheremina O, Bachmakov I, Neubert A, Brune K, Fromm M, Hinz B
Biomed Chromatogr
. 2005 May;
19(10):777-82.
PMID: 15920700
Oxycodone (14-hydroxy-7,8-dihydrocodeinone) is a potent opioid receptor agonist. In the present study, a liquid-liquid extraction-based reversed-phase HPLC method with UV detection was validated and applied for the analysis of oxycodone...
7.
Bachmakov I, Rekersbrink S, Hofmann U, Eichelbaum M, Fromm M
Naunyn Schmiedebergs Arch Pharmacol
. 2005 May;
371(3):195-201.
PMID: 15900513
Digoxin is a drug with a narrow therapeutic index, which is a substrate of the ATP-dependent efflux pump P-glycoprotein. Increased or decreased digoxin plasma concentrations occur in humans due to...