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» Authors » Ioanna Karachristou

Ioanna Karachristou

Explore the profile of Ioanna Karachristou including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 58
Followers 0
Related Specialties
Toxicology
Genetics
Environmental Health
Top 10 Co-Authors
Georgia I Terzoudi
Antonio Pantelias
Gabriel Pantelias
Maria Karakosta
Vasiliki I Hatzi
Pantelis Karaiskos
Panagiotis Dimitriou
Katarzyna Barszczewska
Fabrizio Palitti
Valeria Hadjidekova
Published In
Mutat Res Genet Toxicol Environ Mutagen
Cancers (Basel)
Radiat Prot Dosimetry
Int J Radiat Biol
Affiliations
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Recent Articles
1.
Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis
Pantelias A, Karachristou I, Georgakilas A, Terzoudi G
Cancers (Basel) . 2019 Aug; 11(8). PMID: 31390832
The discovery of chromothripsis in cancer genomes challenges the long-standing concept of carcinogenesis as the result of progressive genetic events. Despite recent advances in describing chromothripsis, its mechanistic origin remains...
2.
Dose assessment intercomparisons within the RENEB network using G-lymphocyte prematurely condensed chromosomes (PCC assay)
Terzoudi G, Pantelias G, Darroudi F, Barszczewska K, Buraczewska I, Depuydt J, et al.
Int J Radiat Biol . 2016 Nov; 93(1):48-57. PMID: 27813725
Purpose: Dose assessment intercomparisons within the RENEB network were performed for triage biodosimetry analyzing G-lymphocyte PCC for harmonization, standardization and optimization of the PCC assay. Materials And Methods: Comparative analysis...
3.
Biodosimetry for High-Dose Exposures Based on Dicentric Analysis in Lymphocytes Released from the G2-Block by Caffeine
Karachristou I, Karakosta M, Pantelias A, Hatzi V, Pantelias G, Thanassoulas A, et al.
Radiat Prot Dosimetry . 2016 Jun; 172(1-3):230-237. PMID: 27344061
High-dose assessments using the conventional dicentric assay are essentially restricted to doses up to 5 Gy and only to lymphocytes that succeed to proceed to first post-exposure mitosis. Since G2-checkpoint...
4.
Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis
Terzoudi G, Karakosta M, Pantelias A, Hatzi V, Karachristou I, Pantelias G
Mutat Res Genet Toxicol Environ Mutagen . 2015 Nov; 793:185-98. PMID: 26520389
Combination of next-generation DNA sequencing, single nucleotide polymorphism array analyses and bioinformatics has revealed the striking phenomenon of chromothripsis, described as complex genomic rearrangements acquired in a single catastrophic event...
5.
Triage biodosimetry using centromeric/telomeric PNA probes and Giemsa staining to score dicentrics or excess fragments in non-stimulated lymphocyte prematurely condensed chromosomes
Karachristou I, Karakosta M, Pantelias A, Hatzi V, Karaiskos P, Dimitriou P, et al.
Mutat Res Genet Toxicol Environ Mutagen . 2015 Nov; 793:107-14. PMID: 26520380
The frequency of dicentric chromosomes in human peripheral blood lymphocytes at metaphase is considered as the "gold-standard" method for biological dosimetry and, presently, it is the most widely used for...
6.
Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH
Hatzi V, Karakosta M, Barszczewska K, Karachristou I, Pantelias G, Terzoudi G
Mutat Res Genet Toxicol Environ Mutagen . 2015 Nov; 793:71-8. PMID: 26520375
The dual role of caffeine as a chromosomal damage inducer and G2/M-checkpoint abrogator is well known but it is observed mainly at relatively high concentrations. At low concentrations, caffeine enhances...