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Ioana R Preston

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Articles 89
Citations 2184
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Recent Articles
1.
Montani D, McLaughlin V, Gibbs J, Gomberg-Maitland M, Hoeper M, Preston I, et al.
Am J Respir Crit Care Med . 2025 Mar; PMID: 40035659
Objectives: To evaluate the effect of genetic variant status on sotatercept efficacy and effect of sotatercept treatment on biomarkers in pulmonary arterial hypertension Methods: PULSAR (NCT03496207) was a phase 2,...
2.
Preston I, Badesch D, Ghofrani H, Gibbs J, Gomberg-Maitland M, Hoeper M, et al.
Eur Respir J . 2025 Feb; PMID: 39978862
Background: SOTERIA (NCT04796337) is an ongoing open-label study evaluating long-term safety, tolerability, and efficacy of sotatercept in participants with pulmonary arterial hypertension (PAH). Methods: Eligible adults with PAH on stable...
3.
Hoeper M, Gomberg-Maitland M, Badesch D, Gibbs J, Grunig E, Kopec G, et al.
Eur Respir J . 2025 Jan; PMID: 39884760
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Sotatercept is a first-in-class activin signalling inhibitor that acts to restore the balance between the...
4.
Gomberg-Maitland M, Badesch D, Gibbs J, Grunig E, Hoeper M, Humbert M, et al.
J Heart Lung Transplant . 2024 Dec; PMID: 39645016
Background: This analysis examined the effects of the activin signaling inhibitor, sotatercept, in pulmonary arterial hypertension (PAH) subgroups stratified by baseline cardiac index (CI). Methods: Pooled data from PULSAR (N ...
5.
Manzi G, Benza R, Argiento P, Casu G, Corda M, Correale M, et al.
Vascul Pharmacol . 2024 Sep; 157:107432. PMID: 39265796
Despite the innovations introduced in the 2022 European Society of Cardiology/European Respiratory Society Guidelines on Pulmonary Hypertension, risk discrimination and management of pulmonary arterial hypertension (PAH) patients at intermediate risk...
6.
Preston I, Howard L, Langleben D, Lichtblau M, Pulido T, Souza R, et al.
Eur Respir J . 2024 Aug; 64(4). PMID: 39209477
Care of pulmonary hypertension (PH) patients in special situations requires insightful knowledge of the pathophysiology of the cardiopulmonary system and close interaction with different specialists, depending on the situation. The...
7.
Preston I, Lewis D, Gomberg-Maitland M
Chest . 2024 Jul; 166(3):604-611. PMID: 39004216
Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary microvasculature leading to elevated precapillary pulmonary hypertension. Pulmonary vascular remodeling, a characteristic of PAH, is driven by dysfunctions in...
8.
Strick D, Farber H, Hill N, Preston I, Pradhan N, Malla B
Chest . 2024 Jul; 166(1):e1-e3. PMID: 38986644
Group 5 pulmonary hypertension (PH) encompasses diverse diseases, with a few cases linking it to T-cell large granular lymphocytic (LGL) leukemia. We report a case of a 76-year-old woman, diagnosed...
9.
Sahay S, Chakinala M, Kim N, Preston I, Thenappan T, McLaughlin V
Am J Respir Crit Care Med . 2024 Jul; 210(5):581-592. PMID: 38984912
Pulmonary arterial hypertension (PAH) is a complex fatal condition that requires aggressive treatment with close monitoring. Significant progress has been made over the last three decades in the treatment of...
10.
Lawrie A, Chin K, Fong Y, Gargano C, Gitton X, He C, et al.
Pulm Circ . 2024 Jun; 14(2):e12386. PMID: 38868397
A blood test identifying patients at increased risk of pulmonary hypertension (PH) could streamline the investigative pathway. The prospective, multicenter CIPHER study aimed to develop a microRNA-based signature for detecting...