Ingo Spreitzer
Overview
Explore the profile of Ingo Spreitzer including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
408
Followers
0
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Recent Articles
1.
Abdin S, Mansel F, Rafiei Hashtchin A, Ackermann M, Hansen G, Becker B, et al.
Biofabrication
. 2024 May;
16(3).
PMID: 38701770
Ensuring the safety of parenteral drugs before injection into patients is of utmost importance. New regulations around the globe and the need to refrain from using animals however, have highlighted...
2.
Baker E, Ponder J, Oberdorfer J, Spreitzer I, Bolden J, Marius M, et al.
Altern Lab Anim
. 2023 Oct;
51(6):401-410.
PMID: 37855095
The Bacterial Endotoxins Test (BET) is a critical safety test that is used to detect bacterial endotoxins, which are the major contributor to fever-inducing contamination risks known as pyrogens. All...
3.
Cirefice G, Schutte K, Spreitzer I, Charton E, Shaid S, Viviani L, et al.
Biologicals
. 2023 Aug;
84:101702.
PMID: 37643507
The rabbit pyrogen test (RPT) was the benchmark for pyrogenicity testing, but scientific advancements have provided innovative and humane methods, such as the in vitro monocyte-activation test (MAT). However, transitioning...
4.
Rossmann L, Bagola K, Stephen T, Gerards A, Walber B, Ullrich A, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34561306
The COVID-19 pandemic highlights the importance of efficient and safe vaccine development. Vaccine adjuvants are essential to boost and tailor the immune response to the corresponding pathogen. To allow for...
5.
Srivastav S, Dankov A, Adanalic M, Grzeschik R, Tran V, Pagel-Wieder S, et al.
Anal Chem
. 2021 Sep;
93(36):12391-12399.
PMID: 34468139
As an immune response to COVID-19 infection, patients develop SARS-CoV-2-specific IgM/IgG antibodies. Here, we compare the performance of a conventional lateral flow assay (LFA) with a surface-enhanced Raman scattering (SERS)-based...
6.
Bolden J, Knutsen C, Levin J, Milne C, Morris T, Mozier N, et al.
PDA J Pharm Sci Technol
. 2020 Aug;
74(5):602-611.
PMID: 32817324
Endotoxin testing by recombinant factor C (rFC) is increasing with the addition of new suppliers of reagents. By use of a recombinantly produced factor C , based on the sequence...
7.
Etna M, Giacomini E, Rizzo F, Severa M, Ricci D, Shaid S, et al.
ALTEX
. 2020 Jun;
37(4):532-544.
PMID: 32488289
Pyrogen content is a key quality feature that must be checked in all injectable products, including vaccines. Four tests are currently available in the European Pharmacopoeia to monitor pyrogen/endotoxin presence:...
8.
Wegner A, Benson S, Rebernik L, Spreitzer I, Jager M, Schedlowski M, et al.
Innate Immun
. 2017 Apr;
23(5):432-439.
PMID: 28443392
Clinical data indicate that inflammatory responses differ across sexes, but the mechanisms remain elusive. Herein, we assessed in vivo and ex vivo cytokine responses to bacterial endotoxin in healthy men...
9.
Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S
Brain Behav Immun
. 2015 Aug;
52:18-26.
PMID: 26291403
Impaired mood and increased anxiety represent core symptoms of sickness behavior that are thought to be mediated by pro-inflammatory cytokines. Moreover, excessive inflammation seems to be implicated in the development...
10.
Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, et al.
J Virol
. 2015 Jan;
89(7):3859-69.
PMID: 25609809
Unlabelled: The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as the causative agent of a severe respiratory disease with a fatality rate of approximately 30%. The high virulence...