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Inge Derese

Explore the profile of Inge Derese including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 50
Citations 1136
Followers 0
Related Specialties
Critical Care
Endocrinology
Genetics
Top 10 Co-Authors
Greet Van den Berghe
Ilse Vanhorebeek
Pieter J Wouters
Fabian Guiza
Jan Gunst
Sarah Derde
Lies Langouche
Sarah Vander Perre
Lies Pauwels
Greet Hermans
Published In
Crit Care
J Clin Endocrinol Metab
Arthritis Rheum
Clin Epigenetics
Intensive Care Med
Affiliations
Soon will be listed here.
Recent Articles
1.
A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart
Jacobs B, Derese I, Derde S, Vander Perre S, Pauwels L, Van den Berghe G, et al.
Intensive Care Med Exp . 2025 Jan; 13(1):6. PMID: 39821755
Background: Sepsis-induced cardiomyopathy (SICM) often occurs in the acute phase of sepsis and is associated with increased mortality due to cardiac dysfunction. The pathogenesis remains poorly understood, and no specific...
2.
Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function
De Bruyn L, Teblick A, Van Oudenhove T, Vander Perre S, Derese I, Pauwels L, et al.
Crit Care . 2024 Sep; 28(1):295. PMID: 39238038
Background: Hypocholesterolemia hallmarks critical illness though the underlying pathophysiology is incompletely understood. As low circulating cholesterol levels could partly be due to an increased conversion to cortisol/corticosterone, we hypothesized that...
3.
Pro-opiomelanocortin and ACTH-cortisol dissociation during pediatric cardiac surgery
Teblick A, Vanhorebeek I, Derese I, Jacobs A, Haghedooren R, Maebe S, et al.
Endocr Connect . 2024 Apr; PMID: 38657653
In critically ill adults, high plasma cortisol in face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC. We hypothesized that in pediatric...
4.
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Coppens G, Vanhorebeek I, Guiza F, Derese I, Wouters P, Teblick A, et al.
Clin Epigenetics . 2024 Feb; 16(1):31. PMID: 38395991
Background: Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus-pituitary-adrenal (HPA) axis which may impair normal brain development, cognition and...
5.
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Vankrunkelsven W, Thiessen S, Derde S, Vervoort E, Derese I, Pintelon I, et al.
Skelet Muscle . 2023 Aug; 13(1):12. PMID: 37537627
Background: Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that...
6.
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time
Vanhorebeek I, Coppens G, Guiza F, Derese I, Wouters P, Joosten K, et al.
Clin Epigenetics . 2023 Jul; 15(1):116. PMID: 37468957
Background: Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in...
7.
The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies
Gunst J, De Bruyn A, Jacobs A, Langouche L, Derese I, Dulfer K, et al.
Crit Care . 2023 Jun; 27(1):251. PMID: 37365667
Background: Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the intervention increased...
8.
Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions
Vanhorebeek I, Gunst J, Casaer M, Derese I, Derde S, Pauwels L, et al.
J Endocr Soc . 2023 Feb; 7(3):bvad001. PMID: 36726836
Context: Muscle expresses and secretes several myokines that bring about benefits in distant organs. Objective: We investigated the impact of critical illness on muscular expression of irisin, kynurenine aminotransferases, and...
9.
Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Verlinden I, Coppens G, Vanhorebeek I, Guiza F, Derese I, Wouters P, et al.
Clin Epigenetics . 2023 Jan; 15(1):8. PMID: 36639798
Background: Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric critical illness, and the...
10.
Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial
Coppens G, Vanhorebeek I, Verlinden I, Derese I, Wouters P, Joosten K, et al.
Epigenetics . 2022 Nov; 18(1):2146966. PMID: 36384393
Critically ill children requiring intensive care suffer from impaired physical/neurocognitive development 2 y later, partially preventable by omitting early use of parenteral nutrition (early-PN) in the paediatric intensive-care-unit (PICU). Altered...