Immacolata Porreca
Overview
Explore the profile of Immacolata Porreca including associated specialties, affiliations and a list of published articles.
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25
Citations
278
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Recent Articles
1.
Porreca I, Blassberg R, Harbottle J, Joubert B, Mielczarek O, Stombaugh J, et al.
Mol Ther
. 2024 Jun;
32(8):2692-2710.
PMID: 38937969
Gene editing technologies hold promise for enabling the next generation of adoptive cellular therapies. In conventional gene editing platforms that rely on nuclease activity, such as clustered regularly interspaced short...
2.
McLaren P, Porreca I, Iaconis G, Mok H, Mukhopadhyay S, Karakoc E, et al.
Nature
. 2023 Sep;
621(7979):E42.
PMID: 37670157
No abstract available.
3.
McLaren P, Porreca I, Iaconis G, Mok H, Mukhopadhyay S, Karakoc E, et al.
Nature
. 2023 Aug;
620(7976):1025-1030.
PMID: 37532928
HIV-1 remains a global health crisis, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa, we assessed...
4.
Peluso T, Nittoli V, Reale C, Porreca I, Russo F, Roberto L, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298533
Early life exposure to Endocrine Disruptor Chemicals (EDCs), such as the organophosphate pesticide Chlorpyrifos (CPF), affects the thyroid activity and dependent process, including the glucose metabolism. The damage of thyroid...
5.
Biondi G, Marrano N, Dipaola L, Borrelli A, Rella M, DOria R, et al.
Diabetes
. 2022 May;
71(8):1763-1771.
PMID: 35612429
We evaluated the role of the p66Shc redox adaptor protein in pancreatic β-cell insulin resistance that develops under lipotoxic conditions and with excess body fat. Prolonged exposure to palmitate in...
6.
Nittoli V, Fortunato A, Fasano G, Coppola U, Gentile A, Maiella S, et al.
Gene
. 2021 Sep;
721S:100011.
PMID: 34530988
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their...
7.
Albano F, Tucci V, Blackshear P, Reale C, Roberto L, Russo F, et al.
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502288
Thyroid hormone levels are usually genetically determined. Thyrocytes produce a unique set of enzymes that are dedicated to thyroid hormone synthesis. While thyroid transcriptional regulation is well-characterized, post-transcriptional mechanisms have...
8.
Colella M, Nittoli V, Porciello A, Porreca I, Reale C, Russo F, et al.
J Endocrinol
. 2020 Aug;
247(1):53-68.
PMID: 32738127
The intra-tissue levels of thyroid hormones (THs) regulate organ functions. Environmental factors can impair these levels by damaging the thyroid gland and/or peripheral TH metabolism. We investigated the effects of...
9.
Mukhopadhyay S, Heinz E, Porreca I, Alasoo K, Yeung A, Yang H, et al.
J Exp Med
. 2019 Dec;
217(2).
PMID: 31819956
Loss of IL-10 signaling in macrophages (Mφs) leads to inflammatory bowel disease (IBD). Induced pluripotent stem cells (iPSCs) were generated from an infantile-onset IBD patient lacking a functional IL10RB gene....
10.
Nittoli V, Fortunato A, Fasano G, Coppola U, Gentile A, Maiella S, et al.
Gene X
. 2019 Jun;
2:100011.
PMID: 31193955
The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes and are orthologs of mouse , we studied their genomic environment...