Ilya Levental
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Explore the profile of Ilya Levental including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Zhang S, Wang H, Tao X, Chen Z, Levental I, Lin X
Langmuir
. 2025 Feb;
41(8):5170-5178.
PMID: 39965093
Recently identified palmitoylation of PD-L1 is essential for immune regulation. To elucidate the underlying molecular mechanism, we performed giant plasma membrane vesicle (GPMV) experiments, μs-scale all-atom molecular dynamics (MD) simulations,...
2.
Gad A, Morris J, Godret-Miertschin L, Montalvo M, Kerr S, Berger H, et al.
Sci Adv
. 2025 Jan;
11(2):eadq8114.
PMID: 39792660
Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics...
3.
Doktorova M, Symons J, Zhang X, Wang H, Schlegel J, Lorent J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713443
Membranes are molecular interfaces that compartmentalize cells to control the flow of nutrients and information. These functions are facilitated by diverse collections of lipids, nearly all of which are distributed...
4.
DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides
Ren Q, Wang J, Idikuda V, Zhang S, Shin J, Ludlam W, et al.
bioRxiv
. 2024 Nov;
PMID: 39574650
Membrane scaffold proteins-based nanodiscs (NDs) have facilitated unprecedented structural and biophysical analysis of membrane proteins in a near-native lipid environment. However, successful reconstitution of membrane proteins in NDs requires prior...
5.
Zimmer S, Giang W, Levental I, Kowalczyk A
Mol Biol Cell
. 2024 Nov;
35(12):ar152.
PMID: 39504468
Cholesterol- and sphingolipid-enriched domains called lipid rafts are hypothesized to selectively coordinate protein complex assembly within the plasma membrane to regulate cellular functions. Desmosomes are mechanically resilient adhesive junctions that...
6.
Doktorova M, Daum S, Ebenhan J, Neudorf S, Han B, Sharma S, et al.
bioRxiv
. 2024 Sep;
PMID: 39257813
Caveolin is a monotopic integral membrane protein, widely expressed in metazoa and responsible for constructing enigmatic membrane invaginations known as caveolae. Recently, the high-resolution structure of a purified human caveolin...
7.
Castello-Serrano I, Heberle F, Diaz-Rohrer B, Ippolito R, Shurer C, Lujan P, et al.
Elife
. 2024 Jun;
12.
PMID: 38837189
The organelles of eukaryotic cells maintain distinct protein and lipid compositions required for their specific functions. The mechanisms by which many of these components are sorted to their specific locations...
8.
Zimmer S, Giang W, Levental I, Kowalczyk A
bioRxiv
. 2024 May;
PMID: 38712246
Cholesterol- and sphingolipid-enriched domains called lipid rafts are hypothesized to selectively coordinate protein complex assembly within the plasma membrane to regulate cellular functions. Desmosomes are mechanically resilient adhesive junctions that...
9.
Amos C, Kiessling V, Kreutzberger A, Schenk N, Mohan R, Nyenhuis S, et al.
Mol Biol Cell
. 2023 Dec;
35(3):ar12.
PMID: 38117594
Insulin secretion depends on the Ca-regulated fusion of granules with the plasma membrane. A recent model of Ca-triggered exocytosis in secretory cells proposes that lipids in the plasma membrane couple...
10.
Doktorova M, Levental I, Heberle F
Cold Spring Harb Perspect Biol
. 2023 Aug;
15(12).
PMID: 37604588
Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises through the concerted...