Il Young Ryu

As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-]thiazol-3(2)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template. Of...

To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve ()-5-(substituted benzylidene)-4-thioxothiazolidin-2-one (()-BTTZ) derivatives were designed...

Thirteen ()-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among the compounds synthesized, compounds - showed greater inhibitory activity than kojic acid (IC =...

We previously reported ()-β-phenyl-α,β-unsaturated carbonyl scaffold (()-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of...

Tyrosinase is considered a key contributor to melanogenesis, and safe, potent tyrosinase inhibitors are needed for medical and cosmetic purposes to treat skin hyperpigmentation and prevent fruit and vegetable browning....

The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 ()-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized. Mushroom tyrosinase inhibitory activities were examined. Compound...

A series of ()-1-(furan-2-yl)prop-2-en-1-one derivatives (compounds -) were synthesized and evaluated for their mushroom tyrosinase inhibitory activity. Among these series, compound (2,4-dihydroxy group bearing benzylidene) showed potent tyrosinase inhibitory activity,...