Ikuo Nakanishi
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Explore the profile of Ikuo Nakanishi including associated specialties, affiliations and a list of published articles.
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97
Citations
579
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Recent Articles
1.
Shimizu W, Shoji Y, Ohkubo K, Ito H, Nakanishi I, Fukuhara K
Antioxidants (Basel)
. 2024 Oct;
13(10).
PMID: 39456420
Planar catechin (PCat), a natural antioxidant with a fixed 3D catechin structure on a plane, exhibits radical-scavenging activity approximately five times stronger than the conventional catechin. We synthesized a compound,...
2.
Indo H, Chatatikun M, Nakanishi I, Matsumoto K, Imai M, Kawakami F, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456251
The universe began 13.8 billion years ago, and Earth was born 4.6 billion years ago. Early traces of life were found as soon as 4.1 billion years ago; then, ~200,000...
3.
Ito H, Shoji Y, Matsumoto K, Fukuhara K, Nakanishi I
Molecules
. 2024 Sep;
29(18).
PMID: 39339462
Catechin is one of the representative antioxidants that shows physiological activities such as an anti-cancer effect. We have developed a chemically modified catechin analog possessing a planar structure, which shows...
4.
Mori R, Abe M, Saimoto Y, Shinto S, Jodai S, Tomomatsu M, et al.
Redox Biol
. 2024 May;
73:103186.
PMID: 38744193
Recent studies have highlighted the indispensable role of oxidized lipids in inflammatory responses, cell death, and disease pathogenesis. Consequently, inhibitors targeting oxidized lipids, particularly lipid-derived radicals critical in lipid peroxidation,...
5.
Shoji Y, Terashima Y, Ohkubo K, Ito H, Maruyama K, Fukuzumi S, et al.
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38674002
2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO), a persistent nitronyl nitroxide radical, has been used for the detection and trapping of nitric oxide, as a redox mediator for batteries, for the activity estimation of...
6.
Ito H, Shoji Y, Matsumoto K, Fukuhara K, Nakanishi I
ACS Med Chem Lett
. 2024 Feb;
15(2):310-313.
PMID: 38352823
Cancer cell migration is related to malignancy and patient prognosis. We previously reported that intracellular reactive oxygen species (ROS) promoted cancer cellular migration and invasion and that an antioxidant enzyme...
7.
Masuda D, Nakanishi I, Ohkubo K, Ito H, Matsumoto K, Ichikawa H, et al.
Biomolecules
. 2024 Jan;
14(1).
PMID: 38275757
Questions about which reactive oxygen species (ROS) or reactive nitrogen species (RNS) can escape from the mitochondria and activate signals must be addressed. In this study, two parameters, the calculated...
8.
Kawabata Y, Fukushige T, Indo H, Matsumoto K, Ueno M, Nakanishi I, et al.
Radiat Res
. 2024 Jan;
201(2):115-125.
PMID: 38211765
The effects of long-term low-dose X-ray irradiation on the outer root sheath (ORS) cells of C3H/He mice were investigated. Mice were irradiated with a regime of 100 mGy/day, 5 days/week,...
9.
Ito H, Shoji Y, Ueno M, Matsumoto K, Nakanishi I
Pharmaceutics
. 2023 Nov;
15(11).
PMID: 38004516
Radiotherapy, in which X-rays are commonly used, is one of the most effective procedures for treating cancer. However, some cancer cells become resistant to radiation therapy, leading to poor prognosis....
10.
Ito H, Shoji Y, Matsumoto K, Fukuhara K, Nakanishi I
ACS Med Chem Lett
. 2023 Oct;
14(10):1478-1481.
PMID: 37849552
Catechin is one of the best-known antioxidants and is reported to have some favorable physiological activities, including anti-cancer effects. We previously synthesized a catechin analog, planar catechin, which showed a...