Ikuko Kimura
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Explore the profile of Ikuko Kimura including associated specialties, affiliations and a list of published articles.
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31
Citations
451
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Recent Articles
11.
Tsuneki H, Sekizaki N, Suzuki T, Kobayashi S, Wada T, Okamoto T, et al.
Eur J Pharmacol
. 2007 Apr;
566(1-3):1-10.
PMID: 17434478
Hyperglycemia-induced oxidative stress plays a crucial role in the pathogenesis of vascular complications in diabetes. Although some clinical evidences suggest the use of an antioxidant reagent coenzyme Q10 in diabetes...
12.
Tsuneki H, Kobayashi S, Takagi K, Kagawa S, Tsunoda M, Murata M, et al.
Mol Pharmacol
. 2006 Nov;
71(3):777-86.
PMID: 17132684
The alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) gene harbors a high degree of polymorphism. In this study, we found a novel variant (1267 G to A) in exon 10 of...
13.
Kimura I
Yakugaku Zasshi
. 2006 Mar;
126(3):133-43.
PMID: 16508237
The multiple pharmacological actions of a unique compound are a prerequisite for classifying drugs as highly efficacious, because the multiple pharmacological actions offer the possibility of treating various symptoms of...
14.
Orihashi M, Shima Y, Tsuneki H, Kimura I
Jpn J Ophthalmol
. 2005 Dec;
49(6):523-526.
PMID: 16365801
Purpose: To compare the ocular hypotensive effect of nipradilol and timolol in combination with bunazosin in rabbits. Methods: The intraocular pressure (IOP) in normal rabbits was measured using an applanation...
15.
Tsuneki H, Ma E, Kobayashi S, Sekizaki N, Maekawa K, Sasaoka T, et al.
Eur J Pharmacol
. 2005 Apr;
512(2-3):105-15.
PMID: 15840394
Abnormal angiogenesis is implicated in various diseases including cancer and diabetic retinopathy. In this study, we examined the effect of beta-eudesmol, a sesquiterpenoid alcohol isolated from Atractylodes lancea rhizome, on...
16.
Tsuneki H, You Y, Toyooka N, Sasaoka T, Nemoto H, Dani J, et al.
Biol Pharm Bull
. 2005 Apr;
28(4):611-4.
PMID: 15802796
Ascidians (sea squirts) contain a wealth of alkaloids, but their influence over neuronal nicotinic acetylcholine receptors (nAChRs) has not been evaluated. In this study, we examined the effects of two...
17.
Kagawa S, Sasaoka T, Yaguchi S, Ishihara H, Tsuneki H, Murakami S, et al.
J Clin Endocrinol Metab
. 2005 Feb;
90(5):2911-9.
PMID: 15687335
Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact...
18.
Kobayashi S, Fukuta M, Suzuki M, Tsuneki H, Kimura I
Biol Pharm Bull
. 2005 Feb;
28(2):242-6.
PMID: 15684477
We have previously reported that the Nepsilon (carboxymethyl)lysine (CML) adduct, a major structure of an advanced glycation end product, facilitates proliferation of CD34+ endothelial progenitor cells budded from cultured choroidal...
19.
Orihashi M, Shima Y, Tsuneki H, Kimura I
Biol Pharm Bull
. 2005 Jan;
28(1):65-8.
PMID: 15635165
The present study was performed to evaluate the intraocular pressure (IOP)-lowering effect of nipradilol in combination with latanoprost on ocular normotensive and hypertensive rabbits. IOP was measured using an applanation...
20.
Tsuneki H, Ito K, Sekizaki N, Ma E, You Y, Kawakami J, et al.
Biol Pharm Bull
. 2004 Dec;
27(12):1951-6.
PMID: 15577211
Nicotinic acetylcholine receptors are found in microvascular endothelial cells. To reveal the functional role in cerebral angiogenic processes, we studied the nicotinic modulation of proliferation activity in cultured bovine and...