Ikue Nagakura
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Explore the profile of Ikue Nagakura including associated specialties, affiliations and a list of published articles.
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11
Citations
251
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Recent Articles
1.
Nong Y, Stoppel D, Johnson M, Boillot M, Todorovic J, Shen J, et al.
bioRxiv
. 2023 Mar;
PMID: 36909588
The circuit origins of aggression in autism spectrum disorder remain undefined. Here we report -expressing glutamatergic neurons in ventrolateral division of ventromedial hypothalamus (VMHvl) drive intermale aggression. Aggression is increased...
2.
DiStasio M, Nagakura I, Nadler M, Anderson M
Ann Neurol
. 2019 Oct;
86(6):885-898.
PMID: 31591744
Objective: Autism spectrum disorder (ASD) affects 1 in 59 children, yet except for rare genetic causes, the etiology in most ASD remains unknown. In the ASD brain, inflammatory cytokine and...
3.
Ip J, Nagakura I, Petravicz J, Li K, Wiemer E, Sur M
J Neurosci
. 2018 Mar;
38(16):3890-3900.
PMID: 29540554
Microdeletion of a region in chromosome 16p11.2 increases susceptibility to autism. Although this region contains exons of 29 genes, disrupting only a small segment of the region, which spans five...
4.
Amaral D, Anderson M, Ansorge O, Chance S, Hare C, Hof P, et al.
Handb Clin Neurol
. 2018 Mar;
150:31-39.
PMID: 29496150
Autism spectrum disorder (ASD or autism) is a neurodevelopmental condition that affects over 1% of the population worldwide. Developing effective preventions and treatments for autism will depend on understanding the...
5.
Krishnan V, Stoppel D, Nong Y, Johnson M, Nadler M, Ozkaynak E, et al.
Nature
. 2017 Mar;
543(7646):507-512.
PMID: 28297715
Maternally inherited 15q11-13 chromosomal triplications cause a frequent and highly penetrant type of autism linked to increased gene dosages of UBE3A, which encodes a ubiquitin ligase with transcriptional co-regulatory functions....
6.
Nagakura I, Van Wart A, Petravicz J, Tropea D, Sur M
J Neurosci
. 2014 Aug;
34(31):10256-63.
PMID: 25080587
Accumulating evidence points to a role for Janus kinase/signal transducers and activators of transcription (STAT) immune signaling in neuronal function; however, its role in experience-dependent plasticity is unknown. Here we...
7.
Sur M, Nagakura I, Chen N, Sugihara H
Prog Brain Res
. 2013 Dec;
207:243-54.
PMID: 24309257
The visual cortex provides powerful evidence for experience-dependent plasticity during development, and for stimulus and reinforcement-dependent plasticity in adulthood. The synaptic and circuit mechanisms underlying such plasticity are being progressively...
8.
Nagakura I, Dunn T, Farah C, Heppner A, Li F, Sossin W
J Neurochem
. 2010 Oct;
115(4):994-1006.
PMID: 20964689
Serotonin (5-hydroxytryptamine, 5HT) is the neurotransmitter that mediates dishabituation in Aplysia. Serotonin mediates this behavioral change through the reversal of synaptic depression in sensory neurons (SNs). However, the 5HT receptors...
9.
Bougie J, Lim T, Farah C, Manjunath V, Nagakura I, Ferraro G, et al.
J Neurochem
. 2009 Mar;
109(4):1129-43.
PMID: 19302474
In vertebrates, a brain-specific transcript from the atypical protein kinase C (PKC) zeta gene encodes protein kinase M (PKM) zeta, a constitutively active kinase implicated in the maintenance of synaptic...
10.
Nagakura I, Ormond J, Sossin W
J Neurosci Res
. 2008 Jun;
86(13):2876-83.
PMID: 18521934
An Aplysia Trk-like receptor (ApTrkl) was previously shown to be involved in cell wide long-term facilitation (LTF) and activation of ERK when serotonin (5-HT) is applied to the cell soma....