Igor N Lebedev
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Explore the profile of Igor N Lebedev including associated specialties, affiliations and a list of published articles.
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34
Citations
266
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Recent Articles
1.
Drozdov G, Kashevarova A, Lebedev I
J Assist Reprod Genet
. 2025 Feb;
PMID: 40019700
The goal of this study was to analyze copy number variations (CNVs) in spontaneous abortions with a euploid karyotype, irrespective of the method used for CNV detection. This systematic review...
2.
Tolmacheva E, Kashevarova A, Fonova E, Salyukova O, Seitova G, Nazarenko L, et al.
Mol Cytogenet
. 2025 Feb;
18(1):3.
PMID: 39985054
Background: The X chromosome is enriched with genes related to brain development, and the hemizygous state of these genes in men causes some difficulties in the clinical interpretation of copy...
3.
Soloveva E, Skleimova M, Minaycheva L, Garaeva A, Zhigalina D, Churkin E, et al.
J Assist Reprod Genet
. 2024 Apr;
41(5):1273-1283.
PMID: 38578603
Purpose: To present the developed preimplantation genetic testing (PGT) for spinocerebellar ataxia type 1 (SCA1) and the outcomes of IVF with PGT. Methods: PGT was performed for two unrelated couples...
4.
Essers R, Lebedev I, Kurg A, Fonova E, Stevens S, Koeck R, et al.
Nat Med
. 2023 Nov;
29(12):3233-3242.
PMID: 37996709
Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development...
5.
Karamysheva T, Gayner T, Elisaphenko E, Trifonov V, Zakirova E, Orishchenko K, et al.
Biomedicines
. 2022 Dec;
10(12).
PMID: 36552011
Detection and precise genomic mapping of balanced chromosomal abnormalities in patients with impaired fertility or a clinical phenotype represent a challenge for current cytogenomics owing to difficulties with precise breakpoint...
6.
Nikitina T, Lebedev I
Cells
. 2022 Jun;
11(12).
PMID: 35741051
Miscarriage affects approximately 15% of clinically recognized pregnancies, and 1-3% of couples experience pregnancy loss recurrently. Approximately 50-60% of miscarriages result from chromosomal abnormalities, whereas up to 60% of euploid...
7.
Fonova E, Tolmacheva E, Kashevarova A, Sazhenova E, Nikitina T, Lopatkina M, et al.
Cytogenet Genome Res
. 2022 May;
162(3):97-108.
PMID: 35636401
Skewed X-chromosome inactivation (sXCI) can be a marker of lethal genetic variants on the X chromosome in a woman since sXCI modifies the pathological phenotype. The aim of this study...
8.
Tolmacheva E, Vasilyev S, Nikitina T, Lytkina E, Sazhenova E, Zhigalina D, et al.
Sci Rep
. 2022 Jan;
12(1):1166.
PMID: 35064135
The presence of an extra chromosome in the embryo karyotype often dramatically affects the fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages. The present study...
9.
Sazhenova E, Nikitina T, Vasilyev S, Tolmacheva E, Vasilyeva O, Markov A, et al.
J Assist Reprod Genet
. 2021 Sep;
38(11):2893-2908.
PMID: 34554362
Purpose: Comparative analysis of multilocus imprinting disturbances (MLIDs) in miscarriages from women with sporadic (SPL) and recurrent pregnancy loss (RPL) and identification of variants in the imprinting control gene NLRP7...
10.
Lebedev I, Zhigalina D
J Assist Reprod Genet
. 2021 Sep;
38(11):2833-2848.
PMID: 34518954
Chromosomal mosaicism is a hallmark of early human embryo development. The last decade yielded an enormous amount of information about diversity and prevalence of mosaicism in preimplantation embryos due to...