Ifor R Beacham
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Explore the profile of Ifor R Beacham including associated specialties, affiliations and a list of published articles.
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29
Citations
1238
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Recent Articles
1.
Musik J, Zalucki Y, Beacham I, Jennings M
Biochim Biophys Acta Biomembr
. 2022 Jul;
1864(10):184000.
PMID: 35798072
Secreted proteins contain an N-terminal signal peptide to guide them through the secretion pathway. Once the protein is translocated, the signal peptide is removed by a signal peptidase, such as...
2.
Walkden H, Delbaz A, Nazareth L, Batzloff M, Shelper T, Beacham I, et al.
PLoS Negl Trop Dis
. 2020 Jan;
14(1):e0008017.
PMID: 31978058
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously...
3.
St John J, Walkden H, Nazareth L, Beagley K, Ulett G, Batzloff M, et al.
Infect Immun
. 2016 Jul;
84(9):2681-8.
PMID: 27382023
Infection with Burkholderia pseudomallei causes melioidosis, a disease with a high mortality rate (20% in Australia and 40% in Southeast Asia). Neurological melioidosis is particularly prevalent in northern Australian patients...
4.
Dando S, Ipe D, Batzloff M, Sullivan M, Crossman D, Crowley M, et al.
Infect Immun
. 2016 Apr;
84(7):1941-1956.
PMID: 27091931
Melioidosis, caused by the bacterium Burkholderia pseudomallei, is an often severe infection that regularly involves respiratory disease following inhalation exposure. Intranasal (i.n.) inoculation of mice represents an experimental approach used...
5.
Bohlmann L, Tredwell G, Yu X, Chang C, Haselhorst T, Winger M, et al.
Nat Chem Biol
. 2015 Nov;
11(12):955-7.
PMID: 26565989
We report the structural and functional characterization of a novel heparanase (BpHep) from the invasive pathogenic bacterium Burkholderia pseudomallei (Bp), showing ∼24% sequence identity with human heparanase (hHep). Site-directed mutagenesis...
6.
Dando S, Mackay-Sim A, Norton R, Currie B, St John J, Ekberg J, et al.
Clin Microbiol Rev
. 2014 Oct;
27(4):691-726.
PMID: 25278572
The brain is well protected against microbial invasion by cellular barriers, such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells within the central nervous...
7.
St John J, Ekberg J, Dando S, Meedeniya A, Horton R, Batzloff M, et al.
mBio
. 2014 Apr;
5(2):e00025.
PMID: 24736221
ABSTRACT Melioidosis is a potentially fatal disease that is endemic to tropical northern Australia and Southeast Asia, with a mortality rate of 14 to 50%. The bacterium Burkholderia pseudomallei is...
8.
Srikhanta Y, Atack J, Beacham I, Jennings M
Biochem Biophys Res Commun
. 2013 Jun;
436(3):362-5.
PMID: 23726917
Escherichia coli expresses two L-asparaginase (EC 3.5.1.1) isozymes: L-asparaginse I, which is a low affinity, cytoplasmic enzyme that is expressed constitutively, and L-asparaginase II, a high affinity periplasmic enzyme that...
9.
Horton R, Grant G, Matthews B, Batzloff M, Owen S, Kyan S, et al.
PLoS One
. 2013 May;
8(5):e63394.
PMID: 23704903
Burkholderia pseudomallei is a Gram-negative environmental bacterium and the causative agent of melioidosis, a potentially fatal, acute or chronic disease endemic in the tropics. Acyl homoserine lactone (AHL)-mediated quorum sensing...
10.
Horton R, Morrison N, Beacham I, Peak I
J Med Microbiol
. 2012 Feb;
61(Pt 5):607-614.
PMID: 22301613
Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic in areas of South-East Asia and northern Australia, and is classed as a category B select agent by the...