Ian Sorrell
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Explore the profile of Ian Sorrell including associated specialties, affiliations and a list of published articles.
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12
Citations
114
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Recent Articles
1.
Li H, Reynolds J, Sorrell I, Sheffield D, Pendlington R, Cubberley R, et al.
Toxicol Appl Pharmacol
. 2022 Mar;
442:115992.
PMID: 35346730
Combined with in vitro bioactivity data, physiologically based kinetic (PBK) models has increasing applications in next generation risk assessment for animal-free safety decision making. A tiered framework of building PBK...
2.
Punt A, Louisse J, Beekmann K, Pinckaers N, Fabian E, van Ravenzwaay B, et al.
ALTEX
. 2022 Jan;
39(2):221–234.
PMID: 35064272
The goal of the present study was to assess the predictive performance of a generic human physiologically based kinetic (PBK) model based on in vitro and in silico input data...
3.
Lester C, Hewitt N, Muller-Vieira U, Mayer M, Ellison C, Duplan H, et al.
Toxicol In Vitro
. 2020 Nov;
72:105051.
PMID: 33188879
Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the impact of chain structure on skin and liver metabolism. Incubations with...
4.
Coleman L, Lian G, Glavin S, Sorrell I, Chen T
Pharm Res
. 2020 Nov;
37(12):241.
PMID: 33175239
Purpose: To advance physiologically-based pharmacokinetic modelling of xenobiotic metabolism by integrating metabolic kinetics with percutaneous absorption. Method: Kinetic rate equations were proposed to describe the metabolism of a network of...
5.
Punt A, Bouwmeester H, Blaauboer B, Coecke S, Hakkert B, Hendriks D, et al.
ALTEX
. 2020 Jun;
37(4):607-622.
PMID: 32521035
For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck....
6.
Hewitt N, Gregoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, et al.
J Appl Toxicol
. 2019 Dec;
40(3):403-415.
PMID: 31867769
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic-relevant chemicals. The penetration of finite doses (10 μL/cm ) of chemicals was...
7.
Moxon T, Li H, Lee M, Piechota P, Nicol B, Pickles J, et al.
Toxicol In Vitro
. 2019 Dec;
63:104746.
PMID: 31837441
Next Generation Risk Assessment (NGRA) is a procedure that integrates new approach methodologies (NAMs) to assure safety of a product without generating data from animal testing. One of the major...
8.
Sorrell I, Shipley R, Regan S, Gardner I, Storm M, Ellis M, et al.
J Theor Biol
. 2019 May;
475:25-33.
PMID: 31100294
A mathematical model has been developed to assist with the development of a hollow fibre bioreactor (HFB) for hepatotoxicity testing of xenobiotics; specifically, to inform the HFB operating set-up, interpret...
9.
Kattou P, Lian G, Glavin S, Sorrell I, Chen T
Pharm Res
. 2017 Jun;
34(10):2036-2048.
PMID: 28660400
Purpose: The development of a new two-dimensional (2D) model to predict follicular permeation, with integration into a recently reported multi-scale model of transdermal permeation is presented. Methods: The follicular pathway...
10.
Storm M, Sorrell I, Shipley R, Regan S, Luetchford K, Sathish J, et al.
J Vis Exp
. 2016 Jun;
(111).
PMID: 27285826
Tissue culture has been used for over 100 years to study cells and responses ex vivo. The convention of this technique is the growth of anchorage dependent cells on the...