Ian R Brown
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Explore the profile of Ian R Brown including associated specialties, affiliations and a list of published articles.
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64
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1100
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Recent Articles
1.
Doolan J, Alesbrook L, Baker K, Brown I, Williams G, Hilton K, et al.
Nat Nanotechnol
. 2023 Jul;
18(9):1060-1066.
PMID: 37400719
Extreme energy-dissipating materials are essential for a range of applications. The military and police force require ballistic armour to ensure the safety of their personnel, while the aerospace industry requires...
2.
Zahonova K, Low R, Warren C, Cantoni D, Herman E, Yiangou L, et al.
Curr Biol
. 2023 Jun;
33(12):2449-2464.e8.
PMID: 37267944
Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis has clearly undergone evolutionary adaptation...
3.
Eastwood T, Baker K, Streather B, Allen N, Wang L, Botchway S, et al.
Cell Rep Methods
. 2023 Mar;
3(2):100396.
PMID: 36936078
We describe an innovative system that exports diverse recombinant proteins in membrane-bound vesicles from . These recombinant vesicles compartmentalize proteins within a micro-environment that enables production of otherwise challenging insoluble,...
4.
Stentz R, Jones E, Juodeikis R, Wegmann U, Guirro M, Goldson A, et al.
Appl Environ Microbiol
. 2022 Aug;
88(16):e0053322.
PMID: 35916501
Bacterial extracellular vesicles (BEVs) released from both Gram-negative and Gram-positive bacteria provide an effective means of communication and trafficking of cell signaling molecules. In the gastrointestinal tract (GIT) BEVs produced...
5.
Cantoni D, Osborne A, Taib N, Thompson G, Martin-Escolano R, Kazana E, et al.
J Eukaryot Microbiol
. 2022 Mar;
69(4):e12908.
PMID: 35322502
The alternative oxidase (AOX) is a protein involved in supporting enzymatic reactions of the Krebs cycle in instances when the canonical (cytochrome-mediated) respiratory chain has been inhibited, while allowing for...
6.
Jinatham V, Cantoni D, Brown I, Vichaslip T, Suwannahitatorn P, Popluechai S, et al.
J Med Microbiol
. 2021 Sep;
70(9).
PMID: 34486973
species are non-photosynthetic trebouxiophyte algae ubiquitously distributed in nature and can be found in sewage and soil. This microbial eukaryote causes human protothecosis in immunocompromised individuals. Thus, presence in the...
7.
Budge J, Knight T, Povey J, Roobol J, Brown I, Singh G, et al.
Data Brief
. 2020 Feb;
29:105217.
PMID: 32071989
The data presented in this article relates to the manuscript entitled 'Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production',...
8.
Juodeikis R, Lee M, Mayer M, Mantell J, Brown I, Verkade P, et al.
Microbiologyopen
. 2020 Feb;
9(5):e1010.
PMID: 32053746
Metabolosomes, catabolic bacterial microcompartments (BMCs), are proteinaceous organelles that are associated with the breakdown of metabolites such as propanediol and ethanolamine. They are composed of an outer multicomponent protein shell...
9.
Budge J, Knight T, Povey J, Roobol J, Brown I, Singh G, et al.
Metab Eng
. 2019 Dec;
57:203-216.
PMID: 31805379
Chinese hamster ovary (CHO) cell expression systems have been exquisitely developed for the production of recombinant biotherapeutics (e.g. standard monoclonal antibodies, mAbs) and are able to generate efficacious, multi-domain proteins...
10.
Li N, Chow A, Ganesh H, Ratnam M, Brown I, Kerman K
Biosensors (Basel)
. 2019 Jul;
9(3).
PMID: 31319551
Altered growth hormone (GH) levels represent a major global health challenge that would benefit from advances in screening methods that are rapid and low cost. Here, we present a miniaturized...