Ian P Tomlinson
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Explore the profile of Ian P Tomlinson including associated specialties, affiliations and a list of published articles.
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42
Citations
2919
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Recent Articles
1.
Thomas M, Su Y, Rosenthal E, Sakoda L, Schmit S, Timofeeva M, et al.
Nat Commun
. 2023 Oct;
14(1):6147.
PMID: 37783704
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry...
2.
Thomas M, Su Y, Rosenthal E, Sakoda L, Schmit S, Timofeeva M, et al.
medRxiv
. 2023 Feb;
PMID: 36789420
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry...
3.
He Y, Zhang X, Timofeeva M, Farrington S, Li X, Xu W, et al.
Int J Cancer
. 2021 Aug;
150(2):303-307.
PMID: 34449871
Epidemiological evidence is consistent with a protective effect of vitamin D against colorectal cancer (CRC), but the observed strong associations are open to confounders and potential reverse causation. Previous Mendelian...
4.
Mikaeel R, Symonds E, Kimber J, Smith E, Horsnell M, Uylaki W, et al.
Asia Pac J Clin Oncol
. 2020 Sep;
17(1):131-138.
PMID: 32885561
Background: Colorectal cancer (CRC) is rising in incidence in young adults, and this observation is currently unexplained. We investigated whether having a personal history of type 2 diabetes mellitus (T2D)...
5.
Grolleman J, de Voer R, Elsayed F, Nielsen M, Weren R, Palles C, et al.
Cancer Cell
. 2019 Feb;
35(2):256-266.e5.
PMID: 30753826
Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations from 17...
6.
He Y, Timofeeva M, Farrington S, Vaughan-Shaw P, Svinti V, Walker M, et al.
BMC Med
. 2018 Aug;
16(1):142.
PMID: 30103784
Background: Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is...
7.
Hollinshead K, Munford H, Eales K, Bardella C, Li C, Escribano-Gonzalez C, et al.
Cell Rep
. 2018 Mar;
22(12):3107-3114.
PMID: 29562167
Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this...
8.
Tanskanen T, van den Berg L, Valimaki N, Aavikko M, Ness-Jensen E, Hveem K, et al.
Int J Cancer
. 2017 Sep;
142(3):540-546.
PMID: 28960316
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to...
9.
May-Wilson S, Sud A, Law P, Palin K, Tuupanen S, Gylfe A, et al.
Eur J Cancer
. 2017 Aug;
84:228-238.
PMID: 28829991
Background: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we...
10.
Rodriguez-Broadbent H, Law P, Sud A, Palin K, Tuupanen S, Gylfe A, et al.
Int J Cancer
. 2017 Mar;
140(12):2701-2708.
PMID: 28340513
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to...