Ian McDowell
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Explore the profile of Ian McDowell including associated specialties, affiliations and a list of published articles.
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63
Citations
4945
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Recent Articles
1.
Bayati A, Ayoubi R, Aguila A, Zorca C, Deyab G, Han C, et al.
Nat Neurosci
. 2024 Oct;
27(12):2401-2416.
PMID: 39379564
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive. Recent evidence indicates that immune dysfunction may...
2.
Wang M, Rieber L, van Baaren J, Morgan M, Merrett S, McDowell I, et al.
CRISPR J
. 2024 Apr;
7(2):120-130.
PMID: 38635326
CRISPR-Cas systems have proven effective in a variety of applications due to their ease of use and relatively high editing efficiency. Yet, any individual CRISPR-Cas system has inherent limitations, necessitating...
3.
Ayoubi R, Ryan J, Biddle M, Alshafie W, Fotouhi M, Gonzalez Bolivar S, et al.
Elife
. 2023 Nov;
12.
PMID: 37995198
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of the...
4.
Shilnikova N, Momoli F, Taher M, Go J, McDowell I, Cashman N, et al.
Aging Ment Health
. 2023 Sep;
28(2):207-226.
PMID: 37691440
Objectives: To synthesize evidence relevant for informed decisions concerning cognitive testing of older physicians. Methods: Relevant literature was systematically searched in Medline, EMBASE, PsycInfo, and ERIC, with key findings abstracted...
5.
Ayoubi R, McDowell I, Fotouhi M, Southern K, McPherson P, Laflamme C
F1000Res
. 2023 Aug;
12:348.
PMID: 37576538
Profilin-1, a member of the Profilin family, is a ubiquitously expressed protein that controls actin polymerization in a concentration-dependent manner. As mutations in the Profilin-1 gene have potential implications in...
6.
Ayoubi R, Ryan J, Biddle M, Alshafie W, Fotouhi M, Gonzalez Bolivar S, et al.
bioRxiv
. 2023 Jul;
PMID: 37398479
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of the...
7.
McDowell I, Ayoubi R, Fotouhi M, Southern K, McPherson P, Laflamme C
F1000Res
. 2023 Jun;
12:355.
PMID: 37359784
Ubiquilin-2, a member of the ubiquilin protein family, plays a role in the regulation of various protein degradation pathways, and is mutated in some neurodegenerative diseases. Well-characterized anti-Ubiquilin-2 antibodies would...
8.
Jones A, Peers K, Wierzbicki A, Ramachandran R, Mansfield M, Dawson C, et al.
Atherosclerosis
. 2023 May;
375:67-74.
PMID: 37253281
Background And Aims: The VOL4002 study assessed the efficacy and safety of volanesorsen in 22 adults with genetically confirmed familial chylomicronaemia syndrome (FCS) treated in the UK Early Access to...
9.
Kabadi A, Machlin L, Dalal N, Lee R, McDowell I, Shah N, et al.
J Cyst Fibros
. 2021 May;
21(1):164-171.
PMID: 34049825
Background: Mechanisms governing the diversity of CFTR gene expression throughout the body are complex. Multiple intronic and distal regulatory elements are responsible for regulating differential CFTR expression across tissues. Methods:...
10.
Ni M, Kim Y, McDowell I, Wong S, Qiu H, Wong I, et al.
Aust N Z J Psychiatry
. 2020 Jan;
54(3):232-243.
PMID: 31989834
Objectives: Protests, riots and revolutions have long been a part of human history and are increasing globally, yet their impact on mental health remains largely unknown. We therefore systematically reviewed...