Ian K Townley
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Explore the profile of Ian K Townley including associated specialties, affiliations and a list of published articles.
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10
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639
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Recent Articles
1.
Townley I, Babin C, Murphy T, Summa C, Rees B
Sci Rep
. 2022 Dec;
12(1):22312.
PMID: 36566251
As aquatic hypoxia worsens on a global scale, fishes will become increasingly challenged by low oxygen, and understanding the molecular basis of their response to hypoxia may help to better...
2.
Townley I, Karchner S, Skripnikova E, Wiese T, Hahn M, Rees B
Am J Physiol Regul Integr Comp Physiol
. 2017 Jan;
312(3):R412-R425.
PMID: 28039194
The hypoxia-inducible factor (HIF) family of transcription factors plays central roles in the development, physiology, pathology, and environmental adaptation of animals. Because many aquatic habitats are characterized by episodes of...
3.
Bonvillain R, Danchuk S, Sullivan D, Betancourt A, Semon J, Eagle M, et al.
Tissue Eng Part A
. 2012 Jul;
18(23-24):2437-52.
PMID: 22764775
Currently, patients with end-stage lung disease are limited to lung transplantation as their only treatment option. Unfortunately, the lungs available for transplantation are few. Moreover, transplant recipients require life-long immune...
4.
Abbaraju N, Boutaghou M, Townley I, Zhang Q, Wang G, Cole R, et al.
Integr Comp Biol
. 2012 Apr;
52(5):626-35.
PMID: 22537935
The Gulf killifish, Fundulus grandis, is a small teleost fish that inhabits marshes of the Gulf of Mexico and demonstrates high tolerance of environmental variation, making it an excellent subject...
5.
Townley I, Schuyler E, Parker-Gur M, Foltz K
Dev Biol
. 2009 Jan;
327(2):465-77.
PMID: 19150445
Egg activation at fertilization in deuterostomes requires a rise in intracellular Ca(2+), which is released from the egg's endoplasmic reticulum. In sea urchins, a Src Family Kinase (SpSFK1) is necessary...
6.
Sodergren E, Weinstock G, Davidson E, Cameron R, Gibbs R, Angerer R, et al.
Science
. 2006 Nov;
314(5801):941-52.
PMID: 17095691
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and...
7.
Roux M, Townley I, Raisch M, Reade A, Bradham C, Humphreys G, et al.
Dev Biol
. 2006 Oct;
300(1):416-33.
PMID: 17054939
The sea urchin egg has a rich history of contributions to our understanding of fundamental questions of egg activation at fertilization. Within seconds of sperm-egg interaction, calcium is released from...
8.
Bradham C, Foltz K, Beane W, Arnone M, Rizzo F, Coffman J, et al.
Dev Biol
. 2006 Oct;
300(1):180-93.
PMID: 17027740
This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both...
9.
Townley I, Roux M, Foltz K
Semin Cell Dev Biol
. 2006 Mar;
17(2):293-302.
PMID: 16545968
Gamete interaction and fusion triggers a number of events that lead to egg activation and development of a new organism. A key event at fertilization is the rise in intracellular...
10.
Michel J, Townley I, Dodge-Kafka K, Zhang F, Kapiloff M, Scott J
Mol Cell
. 2005 Dec;
20(5):661-72.
PMID: 16337591
The muscle A-kinase anchoring protein (mAKAP) tethers cAMP-dependent enzymes to perinuclear membranes of cardiomyocytes. We now demonstrate that two alternatively spliced forms of mAKAP are expressed: mAKAPalpha and mAKAPbeta. The...