Ian J MacRae
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Explore the profile of Ian J MacRae including associated specialties, affiliations and a list of published articles.
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59
Citations
4794
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Recent Articles
1.
Sarkar S, Gebert L, MacRae I
bioRxiv
. 2024 Dec;
PMID: 39677650
Small interfering RNAs (siRNAs) guide mRNA cleavage by human Argonaute2 (hAgo2), leading to targeted gene silencing. Despite their laboratory and clinical impact, structural insights into human siRNA catalytic activity remain...
2.
Dong X, Sheng K, Gebert L, Aiyer S, MacRae I, Lyumkis D, et al.
Nucleic Acids Res
. 2024 Jul;
52(18):11254-11265.
PMID: 39036963
Co-transcriptional assembly is an integral feature of the formation of RNA-protein complexes that mediate translation. For ribosome synthesis, prior studies have indicated that the strict order of transcription of rRNA...
3.
Bastiaanssen C, Ugarte P, Kim K, Finocchio G, Feng Y, Anzelon T, et al.
Nat Commun
. 2024 Jul;
15(1):5499.
PMID: 38951509
Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into...
4.
Dong X, Sheng K, Gebert L, Aiyer S, MacRae I, Lyumkis D, et al.
bioRxiv
. 2024 Apr;
PMID: 38644992
Co-transcriptional assembly is an integral feature of the formation of RNA-protein complexes that mediate translation. For ribosome synthesis, prior studies have indicated that the strict order of transcription of rRNA...
5.
4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification
Kiyuna L, Candido D, Bechara L, Jesus I, Ramalho L, Krum B, et al.
Eur Heart J
. 2023 Nov;
44(44):4696-4712.
PMID: 37944136
Background And Aims: Developing novel therapies to battle the global public health burden of heart failure remains challenging. This study investigates the underlying mechanisms and potential treatment for 4-hydroxynonenal (4-HNE)...
6.
Zolboot N, Xiao Y, Du J, Ghanem M, Choi S, Junn M, et al.
bioRxiv
. 2023 Oct;
PMID: 37808721
Highlights: Fast miRNA loss-of-function with T6B impairs postnatal Purkinje cell developmentReversible T6B reveals critical miRNA windows for dendritogenesis and synaptogenesisConditional Spy3-Ago2 mouse line enables miRNA-target network mapping in rare cellsPurkinje...
7.
Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, et al.
Nature
. 2023 Jun;
619(7969):394-402.
PMID: 37344600
In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make...
8.
Xiao Y, Maeda S, Otomo T, MacRae I
Nat Struct Mol Biol
. 2023 May;
30(6):778-784.
PMID: 37127820
Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in plants and animals. Many AGOs cleave target RNAs using an endoribonuclease activity termed 'slicing'. Slicing by DNA-guided...
9.
Xiao Y, Liu T, MacRae I
EMBO Rep
. 2023 Apr;
24(6):e55806.
PMID: 37082939
Argonaute (AGO) proteins use microRNAs (miRNAs) and small interfering RNAs (siRNAs) as guides to regulate gene expression in plants and animals. AGOs that use miRNAs in bilaterian animals recognize short...
10.
Wiryaman T, MacRae I
Cell
. 2023 Mar;
186(5):903-905.
PMID: 36868213
Phage restriction by adenosine deaminase acting on RNA (RADAR) is a process by which bacteria may alter their own transcriptome to resist bacteriophage. In this issue of Cell, Duncan-Lowey and...