Ian J Hardy
Overview
Explore the profile of Ian J Hardy including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
37
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0
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Recent Articles
1.
Williams H, Nott K, Barrett D, Ward R, Hardy I, Melia C
J Pharm Sci
. 2011 Jul;
100(11):4823-35.
PMID: 21766309
"Biorelevant" media for the fed stomach, including fat emulsions, are routinely used during in vitro testing of solid dosage forms. However, their complexity undoubtedly creates difficulties in identifying factors which...
2.
Williams H, Ward R, Culy A, Hardy I, Melia C
Int J Pharm
. 2010 Sep;
401(1-2):51-9.
PMID: 20858538
High concentrations of dissolved sugars can accelerate in vitro drug release in certain hydroxypropyl methylcellulose (HPMC) matrices (Williams et al., 2009). This study investigated the potential for common formulation variables...
3.
Williams H, Ward R, Hardy I, Melia C
Eur J Pharm Biopharm
. 2010 Sep;
76(3):433-6.
PMID: 20837144
Previous work has shown how high concentrations of sugars can accelerate drug release from hydroxypropyl methylcellulose (HPMC) matrices by suppressing polymer hydration. This study investigates the effects of combining sugar...
4.
Williams H, Barrett D, Ward R, Hardy I, Melia C
J Chromatogr B Analyt Technol Biomed Life Sci
. 2010 May;
878(21):1739-45.
PMID: 20483672
A simple and rapid high-performance liquid-chromatography method is presented that permits quantification of caffeine in colloidal fat emulsions proposed as new 'biorelevant' dissolution media (Intralipid and various milks). Using a...
5.
Williams H, Ward R, Hardy I, Melia C
J Control Release
. 2009 May;
138(3):251-9.
PMID: 19464331
The mechanisms and structure-activity by which dissolved dietary sugars influence drug release from hydroxypropyl methylcellulose (Methocel K4M) matrices were investigated. Drug release was retarded at lower sugar concentrations, but above...
6.
Hardy I, Windberg-Baarup A, Neri C, Byway P, Booth S, Fitzpatrick S
Int J Pharm
. 2007 Feb;
337(1-2):246-53.
PMID: 17306477
Hydrophilic matrix tablets are widely used to extend the release of a broad range of pharmaceutically active materials. The mechanism and kinetics of drug release are dependent on the solubility...
7.
Hardy I, Fitzpatrick S, Booth S
J Pharm Pharmacol
. 2004 Jan;
55(12):1593-9.
PMID: 14738583
Tamp filling processes are widely used for the filling of powders into hard gelatin capsules, whereby capsule fill weight is controlled by the formation of a loosely packed plug of...
8.
Hardy I, Cook W
J Pharm Pharmacol
. 2003 Mar;
55(1):3-18.
PMID: 12625862
There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster...