Ian F C McKenzie
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Explore the profile of Ian F C McKenzie including associated specialties, affiliations and a list of published articles.
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26
Citations
689
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Recent Articles
11.
Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors
Fifis T, Gamvrellis A, Crimeen-Irwin B, Pietersz G, Li J, Mottram P, et al.
J Immunol
. 2004 Aug;
173(5):3148-54.
PMID: 15322175
Infection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In this study, we present a new vaccine...
12.
Xing P, Hu X, Pietersz G, Hosick H, McKenzie I
Cancer Res
. 2004 Jun;
64(11):4018-23.
PMID: 15173016
Cripto, a member of the epidermal growth factor-Cripto-FRL-Criptic (EGF-CFC) family, has been described recently as a potential target for immunotherapy (Adkins et al., J Clin Invest 2003;112:575-87). We have produced...
13.
14.
Loveland B, Milland J, Kyriakou P, Thorley B, Christiansen D, Lanteri M, et al.
Xenotransplantation
. 2004 Feb;
11(2):171-83.
PMID: 14962279
Human membrane cofactor protein (CD46) controls complement activation and when expressed sufficiently as a transgene protects xenografts against complement-mediated rejection, as shown here using non-immunosuppressed baboons and heterotopic CD46 transgenic...
15.
McKenzie I, Li Y, Xing P, Dinatale I, Koulmanda M, Loveland B, et al.
Xenotransplantation
. 2004 Jan;
10(6):615-21.
PMID: 14708531
We have previously reported that islets present in cultured fetal pig pancreas (FPP) are resistant to destruction by Galalpha(1,3)Gal antibodies and compliment, but are susceptible to the 'secondary' antibody response...
16.
Apostolopoulos V, Yuriev E, Ramsland P, Halton J, Osinski C, Li W, et al.
Proc Natl Acad Sci U S A
. 2003 Dec;
100(25):15029-34.
PMID: 14657390
Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide...
17.
Taylor S, McKenzie I, Sandrin M
Glycobiology
. 2003 Mar;
13(5):327-37.
PMID: 12626403
The important xenoepitope Galalpha(1,3)Gal was thought to be exclusively synthesized by a single alpha(1,3)galactosyltransferase. However, the cloning of the distant family member rat iGb3 synthase, which is also capable of...
18.
McKenzie I, Apostolopoulos V, Plebanski M, Pietersz G, Loveland B
Immunol Cell Biol
. 2003 Jan;
81(1):79-85.
PMID: 12534951
Cancer immunotherapy has traditionally undergone a 'revolution' every decade, from the use of Bacille Calmette-Guérin by scarification in the 1970s, to interleukin-2 therapies in the 1980s, and monoclonal antibody treatments...
19.
Taylor S, Osman N, McKenzie I, Sandrin M
Glycobiology
. 2002 Dec;
12(11):729-39.
PMID: 12460941
Historically, the most effective means of modifying cell surface carbohydrates has required the intracellular overexpression of glycosyltransferases or glycosidases and is dependent on the enzymes occupying a cellular localization close...
20.
Bhattacharya N, Wang Z, Davitt C, McKenzie I, Xing P, Magnuson N
Chromosoma
. 2002 Jul;
111(2):80-95.
PMID: 12111331
The proto-oncogene pim-1 is a serine/threonine kinase the over-expression of which promotes lymphoma formation. Neither the normal function of Pim-1 nor the biochemical mechanism for cancer development mediated by the...