Ian Appleton
Overview
Explore the profile of Ian Appleton including associated specialties, affiliations and a list of published articles.
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24
Citations
451
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Recent Articles
1.
McKelvey K, Appleton I
Wounds
. 2015 Apr;
24(3):55-7.
PMID: 25876240
Diabetic foot ulcers are the most severe clinical manifestation of diabetes-related impaired wound healing. Current standard and experimental treatments for these ulcers are largely ineffective. Epicatechin gallate (ECG) is a...
2.
Nair S, Rahman R, Clarkson A, Sutherland B, Taurin S, Sammut I, et al.
J Pineal Res
. 2011 May;
51(3):313-23.
PMID: 21605165
The efficacy of melatonin treatment in experimental stroke has been established. Some of the neuroprotective properties have been attributed to its anti-oxidant and anti-inflammatory effects. Nitric oxide synthases (NOS) and...
3.
Sutherland B, Shaw O, Clarkson A, Winburn I, Errington A, Dixon C, et al.
J Neurosci Res
. 2011 May;
89(8):1284-94.
PMID: 21538467
The contribution of heme oxygenase (HO)-linked pathways to neurodegeneration following cerebral hypoxia-ischemia (HI) remains unclear. We investigated whether HO modulators affected HI-induced brain damage and explored potential mechanisms involved. HI...
4.
Sutherland B, Rahman R, Clarkson A, Shaw O, Nair S, Appleton I
Neurosci Res
. 2009 Aug;
65(4):326-34.
PMID: 19682508
The regional and cellular distribution of heme oxygenase (HO)-1 and -2 following cerebral ischemia has not been ascertained. Employing the transient middle cerebral artery occlusion (MCAO) and hypoxia-ischemia (HI) models...
5.
Pugazhenthi K, Kapoor M, Clarkson A, Hall I, Appleton I
J Pineal Res
. 2008 Jan;
44(4):387-96.
PMID: 18205728
The pineal gland hormone melatonin is known to have both anti-inflammatory and immunomodulatory effects. Given this, we propose that melatonin is an ideal candidate to enhance the process of wound...
6.
Clarkson A, Liu H, Schiborra F, Shaw O, Sammut I, Jackson D, et al.
Brain Res
. 2007 Sep;
1171:111-21.
PMID: 17761153
Cerebral ischemia induces angiogenesis within and around infarcted tissue. The protection of existing and growth of new blood vessels may contribute to a more favorable outcome. The present study assessed...
7.
Ashton J, Rahman R, Nair S, Sutherland B, Glass M, Appleton I
Neurosci Lett
. 2006 Nov;
412(2):114-7.
PMID: 17123706
Until recently the cannabinoid CB2 receptor was believed to be absent from the central nervous system. In this study we have identified CB2 expressing cells that appear in the rat...
8.
Kapoor M, Kojima F, Appleton I, Kawai S, Crofford L
Curr Opin Investig Drugs
. 2006 May;
7(5):418-22.
PMID: 16729717
Skin is an essential protective organ for vertebrate animals. During skin injury, a plethora of cells and mediators occupy the wound site and, through a collective effort, perform repair of...
9.
Sutherland B, Rahman R, Appleton I
J Nutr Biochem
. 2006 Jan;
17(5):291-306.
PMID: 16443357
Catechins are dietary polyphenolic compounds associated with a wide variety of beneficial health effects in vitro, in vivo and clinically. These therapeutic properties have long been attributed to the catechins'...
10.
Clarkson A, Sutherland B, Appleton I
Arch Immunol Ther Exp (Warsz)
. 2005 Jul;
53(3):213-25.
PMID: 15995582
After an hypoxic-ischemic (HI) insult, a multi-faceted complex cascade of events occurs that ultimately causes cell death and neurological damage to the central nervous system. The various cascades include, amongst...