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Ian A Lewis

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Articles 59
Citations 2097
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Recent Articles
1.
King M, Heger K, Drikic M, Mandwal A, Khan A, Sinasac D, et al.
J Inherit Metab Dis . 2025 Mar; 48(2):e70018. PMID: 40033659
The dilated cardiomyopathy with ataxia (DCMA) syndrome is a rare mitochondrial disorder caused by mutations in the poorly understood DNAJC19 gene. Cardiac involvement in DCMA ranges from mild conduction abnormalities...
2.
Chan C, Groves R, Rydzak T, Lewis I
Front Microbiol . 2025 Jan; 15:1507561. PMID: 39744398
Introduction: Urinary tract infections (UTIs) are one of the most prevalent infections in North America and are caused by a diverse range of bacterial species. Although uropathogenesis has been studied...
3.
Alhasan K, King M, Pattar B, Lewis I, Lopaschuk G, Greenway S
Cardiovasc Res . 2024 Nov; 120(17):2166-2178. PMID: 39570879
Heart failure (HF) is a complex syndrome and a leading cause of mortality worldwide. While current medical treatment is based on known pathophysiology and is effective for many patients, the...
4.
Fekete E, Allain T, Sosnowski O, Anderson S, Lewis I, Buret A
Gut Microbes . 2024 Oct; 16(1):2412676. PMID: 39412866
Infection with the protozoan parasite (syn. , ) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood. Mucus consists primarily of densely glycosylated mucin...
5.
Mapar M, Rydzak T, Hommes J, Surewaard B, Lewis I
Trends Microbiol . 2024 Oct; 33(2):223-232. PMID: 39393939
Small colony variants (SCVs) of Staphylococcus aureus are a relatively rare but clinically significant growth morphotype. Infections with SCVs are frequently difficult to treat, inherently antibiotic-resistant, and can lead to...
6.
Arzamendi M, Habibyan Y, Defaye M, Shute A, Baggio C, Chan R, et al.
Gut Microbes . 2024 Oct; 16(1):2409207. PMID: 39360560
Background: Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD...
7.
Urso A, Monk I, Cheng Y, Predella C, Wong Fok Lung T, Theiller E, et al.
Nat Microbiol . 2024 Aug; 9(10):2506-2521. PMID: 39134708
Staphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved...
8.
Ponce L, Bishop S, Wacker S, Groves R, Lewis I
Anal Chem . 2024 Apr; 96(17):6566-6574. PMID: 38642077
Quantitative liquid chromatography-mass spectrometry (LC-MS)-based metabolomics is becoming an important approach for studying complex biological systems but presents several technical challenges that limit its widespread use. Computing metabolite concentrations using...
9.
Mandwal A, Bishop S, Castellanos M, Westlund A, Chaconas G, Davidsen J, et al.
Anal Chem . 2024 Feb; 96(8):3382-3388. PMID: 38359900
Metabolomics is a powerful tool for uncovering biochemical diversity in a wide range of organisms. Metabolic network modeling is commonly used to frame metabolomics data in the context of a...
10.
Hamed S, Mohan A, Navaneetha Krishnan S, Wang A, Drikic M, Prince N, et al.
Gut Microbes . 2023 Dec; 15(2):2281011. PMID: 38078655
Gut bacteria provide benefits to the host and have been implicated in inflammatory bowel disease (IBD), where adherent-invasive (AIEC) pathobionts (., strain LF82) are associated with Crohn's disease. -LF82 causes...