I Wayan Sumardika
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Explore the profile of I Wayan Sumardika including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
359
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Recent Articles
1.
Ota Y, Gao T, Fujisawa M, Sumardika I, Sakaguchi M, Toyooka S, et al.
Pathol Res Pract
. 2024 Nov;
265:155721.
PMID: 39580880
SPRED2 (Sprouty-related, EVH1 domain-containing protein 2), a negative regulator of the ERK1/2 pathway, is downregulated in several cancers; however, the significance of SPRED2 expression in lung adenocarcinoma (LUAD) remains unclear....
2.
Sakaguchi M, Kinoshita R, Tomonobu N, Sakaguchi Y, Futami J, Yamauchi A, et al.
In Vitro Cell Dev Biol Anim
. 2024 Nov;
60(10):1215-1227.
PMID: 39570532
The first-generation pCMViR-TSC, implemented through the promoter sandwich rule, yields 10- to 100-fold higher gene expression than the standard plasmid used with the CMV (cytomegalovirus) or CAG promoter. However, the...
3.
Jiang F, Chen Y, Tomonobu N, Kinoshita R, Komalasari N, Kasano-Camones C, et al.
Front Oncol
. 2024 Jun;
14:1371307.
PMID: 38863623
Background: Triple-negative breast cancer (TNBC) cells are a highly formidable cancer to treat. Nonetheless, by continued investigation into the molecular biology underlying the complex regulation of TNBC cell activity, vulnerabilities...
4.
Takahashi T, Tomonobu N, Kinoshita R, Yamamoto K, Murata H, Komalasari N, et al.
Front Oncol
. 2024 Apr;
14:1371342.
PMID: 38595825
Background: Our earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst to lock annexin A2 on...
5.
Komalasari N, Tomonobu N, Kinoshita R, Chen Y, Sakaguchi Y, Gohara Y, et al.
Front Oncol
. 2023 Apr;
13:1142907.
PMID: 37091157
Background: LOX family members are reported to play pivotal roles in cancer. Unlike their enzymatic activities in collagen cross-linking, their precise cancer functions are unclear. We revealed that LOXL4 is...
6.
Hirabayashi D, Yamamoto K, Maruyama A, Tomonobu N, Kinoshita R, Chen Y, et al.
Front Oncol
. 2023 Mar;
13:1142886.
PMID: 36910659
Background: EMT has been proposed to be a crucial early event in cancer metastasis. EMT is rigidly regulated by the action of several EMT-core transcription factors, particularly ZEB1. We previously...
7.
Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma I, Suzawa K, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142212
The dissection of the complex multistep process of metastasis exposes vulnerabilities that could be exploited to prevent metastasis. To search for possible factors that favor metastatic outgrowth, we have been...
8.
Saito K, Mitsui A, Sumardika I, Yokoyama Y, Sakaguchi M, Kondo E
Int J Oncol
. 2021 Apr;
58(6).
PMID: 33887877
We previously reported that high expression of procollagen‑lysine 2‑oxoglutarate 5‑dioxygenase 2 (PLOD2) leads to stabilization and plasma membrane translocation of integrin β1 to promote the invasion and metastasis of oral...
9.
Bajkowska K, Sumardika I, Tomonobu N, Chen Y, Yamamoto K, Kinoshita R, et al.
Biochem Biophys Rep
. 2020 Jun;
22:100768.
PMID: 32490214
Our recent study revealed an important role of the neuroplastin (NPTN)β downstream signal in lung cancer dissemination in the lung. The molecular mechanism of the signal pathway downstream of NPTNβ...
10.
Tomonobu N, Komalasari N, Sumardika I, Jiang F, Chen Y, Yamamoto K, et al.
Chem Biol Interact
. 2020 Apr;
324:109085.
PMID: 32275922
Herbal medicines and their bioactive compounds are increasingly being recognized as useful drugs for cancer treatments. The parasitic fungus Cordyceps militaris is an attractive anticancer herbal since it shows very...