I Tong Mak
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Explore the profile of I Tong Mak including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
244
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Recent Articles
1.
Elzohary L, Weglicki W, Chmielinska J, Kramer J, Mak I
PLoS One
. 2019 Jan;
14(1):e0210107.
PMID: 30668566
We determined if HIV-1 expression in transgenic (HIV-1-Tg) rats enhanced hepatic genomic changes related to oxidative/nitrosative stress and lipogenesis during cART-treatment, and assessed effects of Mg-supplementation. A clinically used cART...
2.
Mak I, Chmielinska J, Spurney C, Weglicki W, Kramer J
Int J Mol Sci
. 2018 Aug;
19(8).
PMID: 30111743
Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART...
3.
Mak I, Kramer J, Chmielinska J, Spurney C, Weglicki W
J Cardiovasc Pharmacol
. 2014 Oct;
65(1):54-61.
PMID: 25343568
To determine whether the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib may cause hypomagnesemia, inflammation, and cardiac stress, erlotinib was administered to rats (10 mg · kg(-1)· d(-1)) for...
4.
Chen X, Mak I
Free Radic Biol Med
. 2014 Jan;
69:77-85.
PMID: 24434120
Ritonavir (RTV), a prototypical protease inhibitor currently used as a key component of anti-HIV therapy, is known for its endothelial and hepatic toxicity. The effects of RTV and magnesium supplementation...
5.
Mak I, Kramer J, Chen X, Chmielinska J, Spurney C, Weglicki W
Am J Physiol Regul Integr Comp Physiol
. 2013 Sep;
305(10):R1102-11.
PMID: 24049113
Use of protease inhibitors (PI) in HIV patients is associated with hyperlipidemia and increased risk of coronary heart disease. Chronic systemic and cardiac effects of ritonavir (RTV), a universal PI...
6.
McCaffrey T, Tziros C, Lewis J, Katz R, Siegel R, Weglicki W, et al.
Int J Biol Sci
. 2013 May;
9(4):350-60.
PMID: 23630447
Background: Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients. Methods: To...
7.
Mak I, Landgraf K, Chmielinska J, Weglicki W
Can J Physiol Pharmacol
. 2012 Oct;
90(10):1413-8.
PMID: 23067376
Angiotensin may promote endothelial dysfunction through iron accumulation. To research this, bovine endothelial cells (ECs) were incubated with iron (30 µmol·L⁻¹) with or without angiotensin II (100 nmol·L⁻¹). After incubation...
8.
Kramer J, Spurney C, Iantorno M, Tziros C, Chmielinska J, Mak I, et al.
Can J Physiol Pharmacol
. 2012 Aug;
90(9):1257-68.
PMID: 22913465
d-Propranolol (d-Pro: 2-8 mg·(kg body mass)(-1)·day(-1)) protected against cardiac dysfunction and oxidative stress during 3-5 weeks of iron overload (2 mg Fe-dextran·(g body mass)(-1)·week(-1)) in Sprague-Dawley rats. At 3 weeks,...
9.
Weglicki W, Kramer J, Spurney C, Chmielinska J, Mak I
Can J Physiol Pharmacol
. 2012 Jun;
90(8):1145-9.
PMID: 22646904
We determined whether the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamine (tyrphostin AG-1478) causes hypomagnesemia and cardiac dysfunction in rats. Tyrphostin was administered (3 times per week,...
10.
Mak I, Chmielinska J, Kramer J, Spurney C, Weglicki W
Exp Clin Cardiol
. 2011 Dec;
16(4):121-4.
PMID: 22131854
Background/objective: Hypomagnesemia (Hypo-Mg) in rodents leads to neurogenic inflammation associated with substance P (SP) elevations; neutral endopeptidase (NEP) is a principle cell surface proteolytic enzyme, which degrades SP. The effects...