I Simcha
Overview
Explore the profile of I Simcha including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
1295
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0
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Recent Articles
1.
Simcha I, Kirkpatrick C, Sadot E, Shtutman M, Polevoy G, Geiger B, et al.
Mol Biol Cell
. 2001 Apr;
12(4):1177-88.
PMID: 11294915
Drosophila Armadillo and its mammalian homologue beta-catenin are scaffolding proteins involved in the assembly of multiprotein complexes with diverse biological roles. They mediate adherens junction assembly, thus determining tissue architecture,...
2.
Sadot E, Simcha I, Iwai K, Ciechanover A, Geiger B, Ben-Zeev A
Oncogene
. 2000 May;
19(16):1992-2001.
PMID: 10803460
Beta-catenin and plakoglobin are closely related armadillo family proteins with shared and distinct properties; Both are associated with cadherins in actin-containing adherens junctions. Plakoglobin is also found in desmosomes where...
3.
Damalas A, Ben-Zeev A, Simcha I, Shtutman M, Leal J, Zhurinsky J, et al.
EMBO J
. 1999 Jun;
18(11):3054-63.
PMID: 10357817
beta-catenin is a multifunctional protein, acting both as a structural component of the cell adhesion machinery and as a transducer of extracellular signals. Deregulated beta-catenin protein expression, due to mutations...
4.
Shtutman M, Zhurinsky J, Simcha I, Albanese C, DAmico M, Pestell R, et al.
Proc Natl Acad Sci U S A
. 1999 May;
96(10):5522-7.
PMID: 10318916
beta-Catenin plays a dual role in the cell: one in linking the cytoplasmic side of cadherin-mediated cell-cell contacts to the actin cytoskeleton and an additional role in signaling that involves...
5.
Sadot E, Simcha I, Shtutman M, Ben-Zeev A, Geiger B
Proc Natl Acad Sci U S A
. 1998 Dec;
95(26):15339-44.
PMID: 9860970
We studied the effect of N-cadherin, and its free or membrane-anchored cytoplasmic domain, on the level and localization of beta-catenin and on its ability to induce lymphocyte enhancer-binding factor 1...
6.
Simcha I, Shtutman M, Salomon D, Zhurinsky J, Sadot E, Geiger B, et al.
J Cell Biol
. 1998 Jun;
141(6):1433-48.
PMID: 9628899
beta-Catenin and plakoglobin are homologous proteins that function in cell adhesion by linking cadherins to the cytoskeleton and in signaling by transactivation together with lymphoid-enhancing binding/T cell (LEF/TCF) transcription factors....
7.
Salomon D, Sacco P, Roy S, Simcha I, Johnson K, Wheelock M, et al.
J Cell Biol
. 1998 Jan;
139(5):1325-35.
PMID: 9382877
beta-Catenin and plakoglobin (gamma-catenin) are closely related molecules of the armadillo family of proteins. They are localized at the submembrane plaques of cell-cell adherens junctions where they form independent complexes...
8.
Pankov R, Simcha I, Zoller M, Oshima R, Ben-Zeev A
J Cell Sci
. 1997 Apr;
110 ( Pt 8):965-74.
PMID: 9152022
The co-expression of vimentin and keratin-type intermediate filaments in the same cell was often reported to correlate with increased invasiveness and a more aggressive tumorigenic phenotype. To address the possible...
9.
Simcha I, Geiger B, Salomon D, Ben-Zeev A
J Cell Biol
. 1996 Apr;
133(1):199-209.
PMID: 8601608
Plakoglobin is a major component of the submembranal plaque of adherens junctions and desmosomes in mammalian cells. It is closely related to the Drosophila segment polarity gene armadillo which has...
10.
Volberg T, Geiger B, Kam Z, Pankov R, Simcha I, Sabanay H, et al.
J Cell Sci
. 1995 Jun;
108 ( Pt 6):2253-60.
PMID: 7673345
The assembly of focal adhesions was investigated in F9 embryonal carcinoma cells in which the expression of vinculin was eliminated by a targeted disruption of the vinculin gene. Vinculin-deficient F9...